The Effect of Si(IV) Species Derived from Chitosan-Silicate Hydrogels on Osteoblast Behavior

Yuki  Shirosaki; Satoshi Hayakawa; Akiyoshi Osaka

doi:10.4028/www.scientific.net/KEM.493-494.698

Paper Titles

Preparation of Silver-Containing Hydroxyapatite Powder by Ultrasonic Spray-Pyrolysis Technique and its Antibacterial Property
p.678

Dissolution Medium Responsive Simvastatin Release from Biodegradable Apatite Cements Drug Delivery System - The Therapeutically Effect and their Histology in Osteoporosis Rats -
p.684

Preparation of Injectable Hydroxyapatite/Collagen Nanocomposite Artificial Bone
p.689

Investigation of the Phase Separation Occurring during the Injection of β-Tricalcium Phosphate – Water – Glass Beads Pastes
p.693

The Effect of Si(IV) Species Derived from Chitosan-Silicate Hydrogels on Osteoblast Behavior
p.698

Study of the Cytotoxicity of a Composite of Carboxymethylcellulose (CMC) and a BioCeramic (Biphasic Calcium Phosphate-BCP) Injection for Use in Articular Cartilage Repair
p.703

Self Hardening Macroporous Biphasic Calcium Phosphate Bone Void Filler for Bone Reconstruction; Animal Study and Human Data
p.709

Injectable Microparticles of Bioceramic for Bone Reconstruction Animal and Human Applications. HYDROS™ Concept
p.714

Poly(lactic-co-glycolic)/Nanostructured Merwinite Porous Composites for Bone Tissue Engineering. I. Preparation and Morphology
p.718

HomeKey Engineering MaterialsKey Engineering Materials Vols. 493-494The Effect of Si(IV) Species Derived from...

The Effect of Si(IV) Species Derived from Chitosan-Silicate Hydrogels on Osteoblast Behavior

Abstract:

Chitosan-GPTMS (γ-Glycidoxypropyltrimethoxysilane) hybrid hydrogels were synthesized with β-glycerophosphate (β-GP) as the additive agent. Chitosan-GPTMS sols were fluid at room temperature and transformed to hydrogel at 36.5°C in several min. The gelation time of the hydrogels was shortened by the addition of GPTMS. From NMR experiments, this gelation behavior depended on some factors, namely, electrostatic interaction between the phosphate groups of β-GP and the amino groups of chitosan chains, crosslinking between the epoxy groups of GPTMS and the amino groups of chitosan, and polycondensation of the methoxy groups of GPTMS. The Si(IV) released from the hydrogels promoted the cell adhesion and ALP activity of osteoblastic cells MG63.