Dissolution Medium Responsive Simvastatin Release from Biodegradable Apatite Cements Drug Delivery System - The Therapeutically Effect and their Histology in Osteoporosis Rats -

Makoto Otsuka; Hideyuki Hamada; Kuniko Otsuka; Hiroyuki Ohshima

doi:10.4028/www.scientific.net/KEM.493-494.684

Paper Titles

The Effect of Five Polishing Materials on the Surface Roughness of Acrylic and Composite Denture Resins
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Regulating Protein Adsorption onto Hydroxyapatite: Amino Acid Treatment
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Preparation of Calcium-Phosphate Microspheres by Salt-Assisted Ultrasonic Spray-Pyrolysis Technique and their Drug Release Behavior Using Anti-Angiogenic Agent, TNP-470
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Preparation of Silver-Containing Hydroxyapatite Powder by Ultrasonic Spray-Pyrolysis Technique and its Antibacterial Property
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Dissolution Medium Responsive Simvastatin Release from Biodegradable Apatite Cements Drug Delivery System - The Therapeutically Effect and their Histology in Osteoporosis Rats -
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Preparation of Injectable Hydroxyapatite/Collagen Nanocomposite Artificial Bone
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Investigation of the Phase Separation Occurring during the Injection of β-Tricalcium Phosphate – Water – Glass Beads Pastes
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The Effect of Si(IV) Species Derived from Chitosan-Silicate Hydrogels on Osteoblast Behavior
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Study of the Cytotoxicity of a Composite of Carboxymethylcellulose (CMC) and a BioCeramic (Biphasic Calcium Phosphate-BCP) Injection for Use in Articular Cartilage Repair
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 493-494Dissolution Medium Responsive Simvastatin Release...

Dissolution Medium Responsive Simvastatin Release from Biodegradable Apatite Cements Drug Delivery System - The Therapeutically Effect and their Histology in Osteoporosis Rats -

Abstract:

A biodegradable drug delivery system was established using an apatite cement containing simvastatin. The in-vitro drug release from apatite with lower-crystallinity was investigated under simulated osteoblast and osteoclast conditions (SOB and SOC). Apatite cement containing 6% simvastatin had lower crystallinity as the same as natural bone. In-vitro drug release tests were performed under SOB in simulated body fluid (pH 7.8), and then under SOC in acetate buffer (pH4.5) at 37.0｡C, and the process repeated twice. The device had lower drug release rates under SOB, but significantly higher rates under SOC. The simvastatin release rate was 15 times higher under SOC than SOB. The device showed dissolution medium responsive drug release. After implantation of the APC containing simvastatin in osteoporosis rats, the bone mineral density was evaluated by the X-ray computed tomography. The result indicated that the bone mineral density of APC implanted rat was significantly higher than that of control diseased.

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Key Engineering Materials (Volumes 493-494)

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684-688

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https://doi.org/10.4028/www.scientific.net/KEM.493-494.684

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October 2011

Authors:

Makoto Otsuka, Hideyuki Hamada, Kuniko Otsuka, Hiroyuki Ohshima

Keywords:

Bone Mineral Density, Dissolution Medium Responsive Drug Release, Drug Delivery System, Self-Setting Apatite Cement, Simvastatin, X-Ray Computed Tomography

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