Fabrication of 3D Hierarchical Scaffolds by a Hybrid Process Combining Low-Temperature Deposition and Electrospinning

Abstract:

An ideal scaffold should mimic the morphology of the natural extracellular matrix and have good mechanical properties and biologically functional. So, the key point of fabricating of scaffolds is to realize the composition of scaffolds by materials having different physical and biological properties and control porous structure accurately. In this study, we propose a novel technology combining a low-temperature deposition, electrospinning process and freeze-drying to produce a hierarchical 3D biomedical scaffold consisting of micro-sized highly porous chitosan-gelatin strands and nanosized PCL fibers network. Scanning electron microscopy analysis showed that the scaffold composed of parallel aligned micro-strands in a grid-like arrangement layer by layer, along the thickness direction intercalated by a network with randomly distributed nanofibers. The stand of macro-scaffold composed of natural-derived biomaterials and nanofibers composed of synthetic biomaterials were bonded together firmly to form a stable network structure.

• Periodical: Key Engineering Materials (Volume 522)
• Pages: 117-122
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.522.117
• Online since: August 2012
• Authors: Yong Ze Yu, Zhen Zhong Han, Ying Liu, Shu Hui Fang, Yuan Yuan Liu, Qing Xi Hu
• Keywords: Chitosan-Gelatin, Electro-Spinning, Low-Temperature Deposition, Micro/Nanomultilayer Scaffolds, PCL

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