Behavior of Human Blood Adsorption to Biomimetic Functionally Graded Hydroxyapatite

Abstract:

Our approach to the design of biological material scaffolds for bone regeneration is the creation of cell environments that mimic natural tissues. Recently, we confirmed hitologically that the material surfaces of conventional, nonabsorbable ceramics shed body fluid. For bone engineering, it is known that ideal scaffolds should be bioabsorbable, mimetic, and hydrophilic materials that allow for the permeation of liquid components, such as blood and/or extracellular fluid. In our previous study showed functionally graded hydroxyapatite (fg-HAp) absorbed body fluid including albumin. In this study, we investigated the behavior of human blood adsorption to the fg-HAp by using the scanning electron microscope (SEM). The adsorption of the platelets and the formation of the fibrinous network were observed in the fg-HAp group incubated 20 minutes.

• Periodical: Key Engineering Materials (Volumes 529-530)
• Pages: 44-49
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.529-530.44
• Online since: November 2012
• Authors: Junichi Tazaki, S. Yodogawa, Masaru Murata, K. Ito, T. Akazawa, J. Hino, Md.A. Kabir, H. Nagayasu, M. Arisue, T. Shibata, T. Hanawa
• Keywords: Adsorption, Biomimetic, Functionally Graded Hydroxyapatite, Human Blood

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