Evaluation of the Potential In Vivo Genotoxicity of Tungsten (VI) Oxide Nanopowder for Human Health

Abstract:

Tungsten (VI) oxide particles (WO₃, <100 nm particle size) are used for many purposes including production of electro chromic windows, or smart windows, x-ray screen phosphors and gas sensors in everyday life. However, the carcinogenic and genotoxic potential of this nanomaterial have not been sufficiently evaluated. Therefore, the genotoxic potential of WO₃ was examined in Sprague-Dawley rat bone marrow cells by using mitotic index (MI), micronucleus (MN) and chromosome aberrations (CA) assays. Rats were orally gavaged with a single dose of WO₃ (0, 25, 50 and 100 mg/kg) for 30 days. All WO₃ treatments significantly decreased MI rates as compared to the control group. No increase in the incidence of CA was observed at any WO₃ nanoparticle dose in the CA test although MN formation was significantly (P<0.05) increased for 50 and 100 mg/kg doses. The observed alterations in MN and MI parameters reveal that WO₃ has cytotoxic and genotoxic potential and could pose environmental and human health risk.

• Periodical: Key Engineering Materials (Volume 543)
• Pages: 89-92
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.543.89
• Online since: March 2013
• Authors: Hasan Turkez, Bulent Cakmak, Kubra Celik
• Keywords: Biosafety, Genotoxicity, In Vivo, Nanomaterial, Risk Assessment, Tungsten Trioxide

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