A Novel Microfluific Design for Cell Culture and Test

Abstract:

Cellular culture is a complex process for cells are grown under certain given conditions, generally not in vivo. In this paper, a novel microfluidic was designed for cellular culture in a long term. Its structure mainly consists of two parts: channels and chambers. In this architecture, two kinds of channels are designed. One is used to load cell into chambers, the other is for the load of culture solution and drugs. Due to diffusion effect, the culture solution and drugs can permeate into chambers through a amount of ostioles. Finite element simulation was utilized to demonstrast the velocity field distribution and concentration field distribution. Comparisons were made to verify the rationality of the design. The simulation results suggest that this novel microfluidic is appropriate suitable in terms of culturing cells.

• Periodical: Key Engineering Materials (Volumes 562-565)
• Pages: 566-570
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.562-565.566
• Online since: July 2013
• Authors: Wen Dong Zhang, Xiao Liang Tang, Sheng Bo Sang, Shao Bo Du, Peng Wei Li, Jie Hu, Gang Li
• Keywords: Cell Culture, Microfluidic Design, Structure

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