Biomimetic Composites Based on Calcium Phosphates and Chitosan - Hyaluronic Acid with Potential Application in Bone Tissue Engineering

Abstract:

Composites based on calcium phosphates (CP) and mixtures of biopolymers (chitosan and hyaluronic acid) have been prepared by a biomimetic co-precipitation method and tested as scaffolds for bone tissue engineering. The biomimetic strategy is inspired by natural mineralization processes, where the synthesized minerals are usually combined with proteins, polysaccharides or other mineral forms to form composite, in physiological conditions of temperature and pH. Fourier transformed infrared spectroscopy, scanning electron microscopy, X-ray diffraction and XPS analyses confirmed the porous morphology of the scaffolds and formation of various forms of calcium phosphates with amorphous nature. The in vitro degradation studies showed a slow degradation process for CP-biopolymers composites and limited swelling in simulated body fluids. The scaffolds compositions have no negative effect on osteoblasts cell, emphasizing a good biocompatibility.

• Periodical: Key Engineering Materials (Volume 587)
• Pages: 191-196
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.587.191
• Online since: November 2013
• Authors: Florina Daniela Ivan, Andreea Marian, Constantin Edi Tanase, Maria Butnaru, Liliana Verestiuc
• Keywords: Biomimetic, Bone Tissue Engineering, Calcium Phosphate, Chitosan, Composite, Hyaluronic Acid

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