Biodegradability of some Collagen Sponges Reinforced with Different Bioceramics

Abstract:

Composite materials based on collagen matrix could have the different properties in the case of reinforcement with different bioceramics. Not just the chemical composition of bioceramics used as reinforcement component have an influence on the composite properties, but also the microstructural aspects of bioceramics such as morphology, grain size and shape, homogeneity and distribution. We present in this paper the effect of the bioceramics type (TCP, hydroxyapatite) and ratio on the composite material structure and the biodegradation properties of some collagen based composites obtaining using the freeze-drying process. Also, we measure the porosity before made the biodegradation test using collagenase as medium and immersion in simulated body fluid in order to see the bioactivity properties.

• Periodical: Key Engineering Materials (Volume 587)
• Pages: 179-184
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.587.179
• Online since: November 2013
• Authors: Iulian Antoniac*
• Keywords: Biodegradation, Collagen, Composite Material, Freeze-Drying, Hydroxyapatite (HA), β-Tricalcium Phosphate

References

[1] M.G. Albu, Collagen Gels and Matrices for Biomedical Applications, Lambert Academic Publishing, Saarbrücken, Germany, ISBN 3844330577, (2011).

[2] S.V. Dorozhkin, Calcium orthophosphates. J Mater Sci. 42 (2007) 1061–1095.

[3] Racquel Z. LeGeros, Biological and synthetic apatites, in: Brown P.W., Constantz B., editors. Hydroxyapatite and related materials, CRC Press, Boca Raton (1994).

[4] T. Yamamuro, J. Wilson, and L.L. Hench, Handbook of bioactive ceramics: vol. II. Calcium Phosphate and hydroxylapatite ceramics, CRC Press, Boca Raton, Florida, (1990).

DOI: 10.1002/jbm.820250709

[5] K. Nezahat, A. Cuneyt, Synthesis of calcium hydroxyapatite - tricalcium phosphate (HA-TCP) composite bioceramic powders and their sintering behavior, J. Am. Ceram. Soc., 81(9) (1998) 2245-2252.

DOI: 10.1111/j.1151-2916.1998.tb02618.x

[6] M.D. Vranceanu, I. Antoniac, F. Miculescu, R. Saban, The influence of the ceramic phase on the porosity of some biocomposites with collagen matrix used as bone substitutes, Journal of Optoelectronics and Advanced Materials, Vol. 14, 7- 8 (2012).

[7] P. Sepulveda, F.S. Ortega, M.D.M. Innocentini, V.C. Pandolfelli: Properties of highly porous hydroxyapatite obtained by the gel casting of foams. Journal of the American Ceramic Society, 83 (2000) 3021–3024.

DOI: 10.1111/j.1151-2916.2000.tb01677.x

[8] C. Zou, W. Wenga, X. Dengb, K. Chenga, X. Liub, P. Dua, G. Shena, G. Hana, Preparation and characterization of porous β-tricalcium phosphate/collagen composites with an integrated structure, Biomaterials, 26 (2005) 5276-5284.

DOI: 10.1016/j.biomaterials.2005.01.064

[9] Y. Zhang, M. Zhang: Synthesis and characterization of macroporous chitosan/calcium phosphate composite scaffolds for tissue engineering. Journal of Biomedical Materials Research, 55 (2001) 304–312.

DOI: 10.1002/1097-4636(20010605)55:3<304::aid-jbm1018>3.0.co;2-j

[10] H. Bundela, A.K. Bajpai, Designing of hydroxyapatite-gelatin based porous matrix as bone substitute: Correlation with biocompatibility aspects, eXPRESS Polymer Letters, Vol. 2, No. 3 (2008) 201–213.

DOI: 10.3144/expresspolymlett.2008.25

[11] S.B. Cho, K. Nakanishi, T. Kokubo, N. Soga, C. Ohtsuki and T. Nakamura, Apatite formation on silica gel in simulated body fluid: its dependence on structures of silica gels prepared in different media, J. Biomed. Mater. Res, 33 (1995) 145-151.

DOI: 10.1002/(sici)1097-4636(199623)33:3<145::aid-jbm4>3.0.co;2-q

[12] T. Kokubo, H. Takadama, How useful is SBF in predicting in vivo bone bioactivity?, Biomaterials 27 (2006) 2907-2915.

DOI: 10.1016/j.biomaterials.2006.01.017

[13] Y. Jiao, Q. Feng, X. Li, The co-effect of collagen and magnesium ions on calcium carbonate biomineralization, Materials Science and Engineering C, Vol 26; No. 4 (2006) 648-652.

DOI: 10.1016/j.msec.2005.08.038