Bone Substitutes as a Drug Delivery of Antibiotics

Cornelia Ganz; Thomas Gerber

doi:10.4028/www.scientific.net/KEM.631.321

Paper Titles

P19.CL6 Cells Cultured in Apatite-Fiber Scaffold Differentiate into Cardiomyocytes
p.295

Bio-Hybrid Scaffolds for Bone Tissue Engineering: Nano-Hydroxyapatite/Chitosan Composites
p.300

Investigating Approaches for Three-Dimensional Printing of Hydroxyapatite Scaffolds for Bone Regeneration
p.306

pH Effect on the Dissolution Behavior of the Microspheres Containing Strontium Ranelate
p.315

Bone Substitutes as a Drug Delivery of Antibiotics
p.321

Fabrication of Hydroxyapatite Microcapsule Containing Vitamin B₁₂ for Sustained-Release
p.326

Controlled Release of a Protein Using a Ceramic Carrier and Zinc Ions as a Novel Approach to the Treatment of Osteoporosis
p.332

Effect of Surface Silver Ions towards Inhibiting Bacterial Growth on Apatite
p.341

Multiparametric In Vitro Evaluation of Cytocompatibility of 1% Strontium-Containing Nanostructured Hydroxyapatite
p.345

HomeKey Engineering MaterialsKey Engineering Materials Vol. 631Bone Substitutes as a Drug Delivery of Antibiotics

Bone Substitutes as a Drug Delivery of Antibiotics

Abstract:

The aim of the present study was the in vitro investigation of a synthetic bone graft substitute loaded with individual antibiotics for the treatment of osteomyelitis and infectious bone disease. The elution of gentamicin, an aminoglycoside antibiotic, from the NanoBone^® products NanoBone^® S granules (NBG) and lyophilized NanoBone^® (NBP) putty was tested over a period of one week. An indirect photometrically-based detection system was used to measure the released antibiotic concentration. Both materials showed very different release behaviour. After one day lyophilized NanoBone^® putty delivered 100% of the gentamicin value, whereas NanoBone^® S granules released one-fifth of the used gentamicin level.

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Periodical:

Key Engineering Materials (Volume 631)

Pages:

321-325

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.631.321

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Online since:

November 2014

Authors:

Cornelia Ganz*, Thomas Gerber

Keywords:

Antibiotics, Bone Substitute, Drug Release

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References

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