Elastic Blocks: Hydrogel-Embedded Granules as Bone Grafting Substitutes

Franziska Zaage; Michael Dau; Cornelia Ganz; Bernhard Frerich; Thomas Gerber

doi:10.4028/www.scientific.net/KEM.631.414

Paper Titles

Evaluation of the Effects of Ag Ion Concentration on Osteoblast Activity
p.390

Development of Bioresorbable Calcium-Phosphate Cements Hybridized with Gelatin Particles and their In Vivo Evaluation Using Pig’s Tibia Model
p.397

In Vivo Evaluation of Chelate-Setting Cement Fabricated from Hydroxyapatite Including Bone Minerals Using a Rabbit’s Tibia Model
p.402

Ex Vivo Model for Percutaneous Vertebroplasty
p.408

Elastic Blocks: Hydrogel-Embedded Granules as Bone Grafting Substitutes
p.414

A Histological and Radiological Study of Bone Formation around Porous Resorbable β-Tricalcium Phosphate Used as Bone Defect Filling
p.420

In Vivo Osteogenesis Assessment of a Tricalcium Phosphate Paste and a Tricalcium Phosphate Foam Bone Grafting Materials
p.426

Bone Induction in Porous HAp Block Modified by Partial Dissolution-Precipitation Technique with Supersonic Treatment in Rat Scalp
p.430

Poly (L-Lactic Acid) and Hydroxyapatite Scaffold for Bone Regeneration: In Vivo Study
p.435

HomeKey Engineering MaterialsKey Engineering Materials Vol. 631Elastic Blocks: Hydrogel-Embedded Granules as Bone...

Elastic Blocks: Hydrogel-Embedded Granules as Bone Grafting Substitutes

Abstract:

NanoBone^®Block is the alternative to autogenous bone blocks and offers doctors a rapid, simple operating procedure in combination with a low risk of complications. Aim of this work was to develop a bone grafting block with elastic properties for dental and orthopedic surgery which is ready to use. An easy handling has to be connected with quick regeneration. Therefore, NB granules have been combined with an elastic hydrogel carrier based on Polyvinylpyrrolidone (PVP) and silica sol. Mechanical properties were optimized for an enhanced handling by cross linking and simultaneous sterilization of the PVP with gamma radiation. Cross linked PVP has the capability of swelling in water without being solved. To approve biocompatibility of adjusted material an in vivo study was analyzed using a standardized bone defect model in rat tibiae. Defect was filled with elastic bone grafting material. After 21 and 63 days rats were sacrificed and tibias analyzed. Histomorphological analysis showed an increased bone formation but even a decelerated resorption of elastic biomaterial. Quantitative compositional analysis showed a decrease in silicon content of granules as a process of matrix change.

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Periodical:

Key Engineering Materials (Volume 631)

Pages:

414-419

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.631.414

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Online since:

November 2014

Authors:

Franziska Zaage*, Michael Dau, Cornelia Ganz, Bernhard Frerich, Thomas Gerber

Keywords:

Bone Substitute, Cross Linking, Gamma Sterilization, Histomorphometry

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