Calcium Phosphate-Loaded Strips, Plugs and Putties: Physico-Chemical Properties for Osteopromotion and Ease of Surgery

Article Preview

Abstract:

The present study focuses on the physico-chemical and structural properties of composite scaffolds composed of biopolymer matrices (collagen or polysaccharide) loaded with calcium phosphate granules. A systematic three-dimensional analysis method was used to quantitatively characterize a series of plugs, strips and putties in terms of percentage of inorganic filler particles, size of the loaded granules, and spatial homogeneity of the calcium phosphate granules distribution. It appears clearly that each biomaterial currently available on the market offers specific properties. As a consequence, surgeons have to choose the medical device that best suits their needs depending on the clinical constraints but also should be aware of the mineral properties which remains key to bone reconstruction.

You might also be interested in these eBooks

Info:

Periodical:

Pages:

83-87

Citation:

Online since:

November 2014

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2015 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

[1] Logeart‐Avramoglou, D., et al., Engineering bone: challenges and obstacles. J. Cell. Mol. Med. 9(2005) 72-84.

Google Scholar

[2] Damien, C. J., & Parsons, J. R. Bone graft and bone graft substitutes: a review of current technology and applications. J. Appl. Biomater. 2 (1991) 187-208.

DOI: 10.1002/jab.770020307

Google Scholar

[3] Teng, S.H., et al., Three‐layered membranes of collagen/hydroxyapatite and chitosan for guided bone regeneration, J. Biomed. Mater. Res., Part B. 87 (2008) 132-138.

DOI: 10.1002/jbm.b.31082

Google Scholar

[4] Daculsi, G., et al., Current state of the art of biphasic calcium phosphate bioceramics, J. Mater. Sci.: Mater. Med. 14 (2003) 195-200.

Google Scholar

[5] Pennesi, G., et al., Regulatory influence of scaffolds on cell behavior: how cells decode biomaterials, Curr. Pharm. Biotechnol. 12 (2011) 151-159.

DOI: 10.2174/138920111794295684

Google Scholar

[6] Ferretti, C., et al., Osteoinduction: translating preclinical promise into clinical reality, Brit. J. Oral Max. Surg. 48 (2010) 536-539.

DOI: 10.1016/j.bjoms.2009.08.043

Google Scholar

[7] Kanczler, J. and R. Oreffo, Osteogenesis and angiogenesis: the potential for engineering bone, Eur. Cell. Mater. 15 (2008) 100-114.

Google Scholar

[8] Li, S. et al., Macroporous biphasic calcium phosphate scaffold with high permeability/porosity ratio. Tissue Eng. 9 (2003) 535-48.

DOI: 10.1089/107632703322066714

Google Scholar

[9] Hutmacher, D.W., et al., State of the art and future directions of scaffold‐based bone engineering from a biomaterials perspective, J. Tissue Eng. Regen. Med. 1 (2007) 245-260.

DOI: 10.1002/term.24

Google Scholar

[10] Ellingsworth, L.R., et al., The human immune response to reconstituted bovine collagen, J. Immunol. 136 (1986) 877-882.

DOI: 10.4049/jimmunol.136.3.877

Google Scholar

[11] Mastrogiacomo, M., et al. Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics. Biomaterials 27 (2006) 3230-3237.

DOI: 10.1016/j.biomaterials.2006.01.031

Google Scholar