New Flexible Cyanoacrylate Tissue Adhesive Adhflex^®: Adhesion and Performance in Inguinal Hernia Repair

Abstract:

Sutures and cyanoacrylate high strength tissue adhesives are commonly used for wound closure in several surgical applications. Although effective for closing simple and small incisions, cyanoacrylate adhesives were limited by compromising adhesion and stiffness, i.e. cyanoacrylates with short alkyl chain length showed higher adhesion but lower flexibility than the ones with long alkyl chain length. In this paper, a new concept of flexible and high strength tissue cyanoacrylate based adhesive - Adhflex^®- is presented. The balance between adhesion and flexibility in Adhflex® was achieved by adding an inert (i.e. non-reactive) chemical to a short alkyl chain length cyanoacrylate able to partially inhibit its polymerization in presence of moisture. Adhesion properties of Adhflex^® were superior as compared to other commercial cyanoacrylate tissue adhesives (i.e. higher traction and shear strength). Furthermore, Adhflex^® has been successfully used in a clinical trial for inguinal hernia repair (case study) as the surgery time with respect to suturing was reduced substantially, the comfort of the patient was improved (i.e. reduced tension after surgery, reduced allergic reaction) and the scare was minimal.

• Periodical: Key Engineering Materials (Volume 638)
• Pages: 73-78
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.638.73
• Online since: March 2015
• Authors: Ana M. Villarreal-Gómez, Manuel Martínez-Paíno, José Miguel Martín-Martínez
• Keywords: Adhesion, Cyanoacrylate, Flexibility, Inguinal Hernia Repair, Tissue Adhesive

References

[1] J.V. Quinn, Overview of tissue adhesives, in: J.V. Quinn, Tissue adhesives in clinical medicine, 2nd ed., BC Decker, Ontario, 2005, pp.1-13.

[2] A.J. Singer, J.V. Quinn, J.E. Hollander, The cyanoacrylate topical skin adhesives, Am J Emerg Med. 26 (2008) 490-6.

[3] J.E. Hollander, A.J. Singer, Laceration management, Ann Emerg Med. 34 (1999) 356-67.

[4] R. Farouk, P. J. Drew, A. Qureshi, A. C. Roberts, G. S. Duthie, J. R. T. Monson, Preliminary experience with butyl-2-cyanoacrylate adhesive in tension-free inguinal hernia repair, British Journal of Surgery 83 (1996) 1095-1100.

DOI: 10.1002/bjs.1800830819

[5] A. Qureshi , P.J. Drew, G.S. Duthie, A.C. Roberts, J.R. Monson, n-butyl cyanoacrylate adhesive for skin closure of abdominal wounds: Preliminary results, Ann R Coll Surg Engl 79 (1997) 414-5.

[6] S. Maartense, W.A. Bemelman, M.S. Dunker, C. De Lint, E.G.J.M. JPierik, O.R.C. Busch, Randomized study of the effectiveness of closing laparoscopic trocar wounds with octylcyanoacrylate, adhesive papertape or poliglecaprone, British Journal Surg 89 (2002).

DOI: 10.1046/j.1365-2168.2002.02235.x

[7] C. Helbling, R. Schlumpf, Sutureless Lichtenstein: first results of a prospective randomized clinical trial Hernia, Epub 7 (2003) 80-4.

DOI: 10.1007/s10029-002-0114-9

[8] S.F. Matin, Prospective randomized trial of skin adhesive versus sutures for closure of 217 laparoscopic port-site incisions, J Am Coll Surg. 196 (2003) 845-53.

DOI: 10.1016/s1072-7515(03)00119-4

[9] M.J. Sebesta, J.T. Bishoff, Octylcyanoacrylate skin closure in laparoscopy, J Endourol. 17 (2003) 899-903.

DOI: 10.1089/089277903772036235

[10] E.F. Switzer, R.C. Dinsmore, J.H. North Jr, Subcuticular closure versus Dermabond: A prospective randomized trial, Am Surg. 69 (2003) 434-6.

DOI: 10.1177/000313480306900515