Fabrication of Three Dimensional Structures in Polymer-Based Microchannels with Lost-Wax Casting Method

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Polymer materials have been utilized in microfluidic devices because of their properties and competitive cost for single-use devices. However, most microfabrication processes can not produce true three dimensional features in polymers. In this study, a new method with lost-wax casting was proposed to fabricate three dimensional microstructures in polymer-based microchannels. A feasibility study was conducted with epoxy and paraffin wax sacrifice. The microchannel with both-end fixed horizontal rods was produced with precise dimension. This structure is not possible to be fabricated by other replicating methods such as hot embossing or casting. The proposed lost-wax casting process is expected to advance the development of three dimensional polymer-based microchips for both the experimental research in laboratory and the mass production in industry.

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120-127

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June 2015

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© 2015 Trans Tech Publications Ltd. All Rights Reserved

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[1] A. Manz, N. Graber, and H. M. Widmer, Miniaturized Total Chemical Analysis Systems. A Novel Concept for Chemical Sensing. Sensors and Actuators, B: Chemical, B1, (1990) 244-248.

DOI: 10.1016/0925-4005(90)80209-i

Google Scholar

[2] C. Zhang, D. Xing, and Y. Li, Micropumps, Microvalves, and Micromixers within Pcr Microfluidic Chips: Advances and Trends. Biotechnology Advances, 25, (2007) 483-514.

DOI: 10.1016/j.biotechadv.2007.05.003

Google Scholar

[3] H. Becker and C. Gartner, Polymer Microfabrication Technologies for Microfluidic Systems. Analytical and Bioanalytical Chemistry, 390, (2008) 89-111.

DOI: 10.1007/s00216-007-1692-2

Google Scholar

[4] A. Waldbaur, H. Rapp, K. Lange, and B. E. Rapp, Let There Be Chip - Towards Rapid Prototyping of Microfluidic Devices: One-Step Manufacturing Processes. Analytical Methods, 3, (2011) 2681-2716.

DOI: 10.1039/c1ay05253e

Google Scholar

[5] A. Alrifaiy, O. A. Lindahl, and K. Ramser, Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering. Polymers, 4, (2012) 1349-1398.

DOI: 10.3390/polym4031349

Google Scholar

[6] M. K. S. Verma, A. Majumder, and A. Ghatak, Embedded Template-Assisted Fabrication of Complex Microchannels in Pdms and Design of a Microfluidic Adhesive. Langmuir, 22, (2006) 10291-10295.

DOI: 10.1021/la062516n

Google Scholar

[7] A. D. Stroock, S. K. W. Dertinger, A. Ajdari, I. Mezić, H. A. Stone, and G. M. Whitesides, Chaotic Mixer for Microchannels. Science, 295, (2002) 647-651.

DOI: 10.1126/science.1066238

Google Scholar

[8] A. P. Sudarsan and V. M. Ugaz, Fluid Mixing in Planar Spiral Microchannels. Lab on a Chip, 6, (2006) 74-82.

DOI: 10.1039/b511524h

Google Scholar

[9] Y. W. Kim and J. Y. Yoo, Three-Dimensional Focusing of Red Blood Cells in Microchannel Flows for Bio-Sensing Applications. Biosensors and Bioelectronics, 24, (2009) 3677-3682.

DOI: 10.1016/j.bios.2009.05.037

Google Scholar

[10] R. H. Liu, M. A. Stremler, K. V. Sharp, M. G. Olsen, J. G. Santiago, R. J. Adrian, H. Aref, and D. J. Beebe, Passive Mixing in a Three-Dimensional Serpentine Microchannel. Microelectromechanical Systems, Journal of, 9, (2000) 190-197.

DOI: 10.1109/84.846699

Google Scholar

[11] M. N. De Silva, J. Paulsen, M. J. Renn, and D. J. Odde, Two-Step Cell Patterning on Planar and Complex Curved Surfaces by Precision Spraying of Polymers. Biotechnology and Bioengineering, 93, (2006) 919-927.

DOI: 10.1002/bit.20787

Google Scholar

[12] A. Folch and M. Toner, Cellular Micropatterns on Biocompatible Materials. Biotechnology Progress, 14, (1998) 388-392.

DOI: 10.1021/bp980037b

Google Scholar

[13] D. T. Chiu, N. L. Jeon, S. Huang, R. S. Kane, C. J. Wargo, I. S. Choi, D. E. Ingber, and G. M. Whitesides, Patterned Deposition of Cells and Proteins onto Surfaces by Using Three-Dimensional Microfluidic Systems. Proceedings of the National Academy of Sciences, 97, (2000).

DOI: 10.1073/pnas.040562297

Google Scholar

[14] N. -T. Nguyen and Z. Wu, Micromixers - a Review. Journal of Micromechanics and Microengineering, 15, (2005) R1-R16.

DOI: 10.1088/0960-1317/15/2/r01

Google Scholar

[15] V. Hessel, H. Löwe, and F. Schönfeld, Micromixers—a Review on Passive and Active Mixing Principles. Chemical Engineering Science, 60, (2005) 2479-2501.

DOI: 10.1016/j.ces.2004.11.033

Google Scholar

[16] A. W. Browne, M. J. Rust, W. Jung, S. H. Lee, and C. H. Ahn, A Rapid Prototyping Method for Polymer Microfluidics with Fixed Aspect Ratio and 3d Tapered Channels. Lab Chip, 9, (2009) 2941-2946.

DOI: 10.1039/b903755a

Google Scholar

[17] M. Vaezi, H. Seitz, and S. Yang, A Review on 3d Micro-Additive Manufacturing Technologies. International Journal of Advanced Manufacturing Technology, 67, (2013) 1721-1754.

DOI: 10.1007/s00170-012-4605-2

Google Scholar

[18] The Dow Chemical Company. Epoxy Resins Product Overview [cited 2014 July 14]; Available from: http: /msdssearch. dow. com/PublishedLiteratureDOWCOM/dh_03ee/0901b803803ee43d. pdf?filepath=/296-01885. pdf&fromPage=GetDoc.

Google Scholar

[19] A. J. T. Scarr, Metrology and Precision Engineering,London, New York McGraw-Hill,(1967).

Google Scholar

[20] Y. Lin, G. J. Gerfen, D. L. Rousseau, and S. -R. Yeh, Ultrafast Microfluidic Mixer and Freeze-Quenching Device. Analytical Chemistry, 75, (2003) 5381-5386.

DOI: 10.1021/ac0346205

Google Scholar