Tissue Reaction to Subcutaneous Implantation of SuperEBA (Reinforced Zinc Oxide Cement) Used as Root-End Filling Material: A Histological Study in Rats

Abstract:

The retrograde filling is a critical step to a successful outcome of the endodontic surgery. Despite the progress in the technology of novel root-end filling materials, zinc oxide-eugenol cement superEBA is still preserving its clinical value on long-term basis. The study aimed to reconsider the tissue response to the initial irritating effect of this material. Silicon tubes filled with superEBA were subcutaneously implanted for 120 days in white Wistar rats which were afterwards sacrificed. The connective tissue surrounding the superEBA implants revealed fibroblast proliferation and a definite reparatory process without inflammatory reaction. A non-specific tissue healing in progress around the implants, without calcifications, necrosis, and apoptosis was also described after 4 months. SuperEBA proved on animal model that its cytotoxicity is reducing gradually in time until no adverse reaction is observed. The reduced content in eugenol compared to other surgical zinc oxide cements and the benefic effect of o-ethoxybenzoic acid are the support to reconsider SuperEBA as a biocompatible retrograde filling material.

• Periodical: Key Engineering Materials (Volume 695)
• Pages: 247-251
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.695.247
• Online since: May 2016
• Authors: Alexandru Andrei Iliescu, Cristian Marian Petcu*, Ileana Cristiana Petcu, Irina Maria Gheorghiu, Andrei Iliescu, Mihaela Georgiana Stan, Sabina Andrada Zurac
• Keywords: Biocompatibility, Histology, Root-End Filling, SuperEBA

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