Application of Fluorine Containing Bioactive Glass Nanoparticles in Dentin Hypersensitivity Treatment

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Abstract:

The effect of Bioactive Glass on remineralization of dentin is the focus of the present study due to its excellent regenerative properties in mineralized tissues. It is known that the effect of Bioactive Glass can be enhanced at the nanoscale. In addition, the incorporation of Fluorine in the glass structure makes possible the formation of Fluorapatite (FAP). The aim of this study was to synthesize and characterize a new system of Fluorine containing Bioactive Glass Nanoparticles (FBGNP), and evaluate the potential for in vitro dentin remineralization by occlusion of dentinal tubules. The FBGNPs produced were uniform, with spherical shape and nanoscale size. Agglomeration or partial sinterization of the particulate system probably occurred after heat treatment. The results suggest the formation of FAP crystals embedded within the matrix of the Bioactive Glass. The gel containing FBGNP produced was effective in obliterating the dentinal tubules in vitro, showing that FBGNP is a potential material to be used for treatment of dentin hypersensitivity.

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