Magnetite/Hydroxyapatite Composite Particles-Assisted Pore Alignment of Tilapia Fish Scale Collagen-Based Scaffold

Abstract:

Pore alignment is a vital step to obtain bone-mimicking microstructure in collagen-based scaffold. The porous structure can be controlled by altering the configuration of ice crystals formed in collagen solution. In this study, movements of magnetite/hydroxyapatite composite particles were used to alter the configuration of pore alignment formed in 1.0 and 1.5wt% collagen solutions (HCol 1.0 and HCol 1.5 respectively) by applying moving external magnetic field. In case of HCol 1.0 pores were aligned parallel to the magnetic field, while for HCol 1.5 pores were aligned at curve shape. Different results of pore alignment were thought to originate from differences in collagen fiber alignment caused by magnetic particles movement paths. This result thus opens up the possibility of controlling pore alignment by utilizing magnetic particle movement.

• Periodical: Key Engineering Materials (Volume 696)
• Pages: 121-128
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.696.121
• Online since: May 2016
• Authors: Vincent Irawan, Tomomei Sugiyama, Toshiyuki Ikoma
• Keywords: Hydroxyapatite-Magnetic Nanoparticles, Magnetic Field, Porosity Alignment, Tilapia Collagen Scaffold

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