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Fabrication of Hydroxyapatite Microcapsules for Controlled Release of Hydrophobic Drug

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Abstract:

Hydroxyapatite (HAp), a principal component of living bone and teeth, is collecting a lot of attention as a biomaterial owing to its biocompatibility. Also, HAp formed in simulated body fluid (SBF) has flake-like structure and porous body. From these properties, in this study, we fabricated HAp microcapsules encapsulating ibuprofen by attaching the Apatite Nuclei (ANs) on oil droplets containing the ibuprofen and soaking the mixture in SBF. In addition, we evaluated the behavior of drug release from the microcapsules In Vitro.

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Bioceramics 28 View Preview

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Periodical:

Key Engineering Materials (Volume 720)

Pages:

12-16

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.720.12

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Online since:

November 2016

Authors:

Takahiko Matsunaga, Takeshi Yabutsuka*, Shigeomi Takai, Takeshi Yao

Keywords:

Apatite Nuclei (AN), Hydrophobic Drug, Hydroxyapatite Microcapsule, Simulated Body Fluid, Sustainable Release

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