Chlorhexidine Adsorption in Hydroxyapatite and Alginate Microspheres by Extrusion in Zinc and Calcium Chloride

Abstract:

In this work, the adsorption of a low-concentration solution of chlorhexidine (CHX), an antimicrobial drug, in hydroxyapatite (HA) and alginate microspheres was studied. The microspheres were formed by extrusion of a 1:10 mixture of alginate and HA in two different divalent solutions: CaCl₂ and ZnCl₂. UV-Vis spectroscopy showed that the microspheres adsorbed approximately half of the chlorhexidine in solution, which was initially at 0.2%. XRD patterns obtained prior adsorption confirmed the presence of HA as the only crystalline phase. Scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) analysis were performed before and after CHX adsorption. The spheres produced in CaCl₂ solution did not show significant change after adsorption. However, samples obtained in ZnCl₂ solution showed a different microstructure, with the presence of crystals with a high Zn concentration. X-Ray Fluorescence (XRF) confirmed the presence of ZnO in the samples after CHX absorption.

• Periodical: Key Engineering Materials (Volume 720)
• Pages: 25-30
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.720.25
• Online since: November 2016
• Authors: Nadia Mohammed Elmassalami Ayad, Daniel Navarro da Rocha, Andrea Machado Costa, Marcelo Henrique Prado da Silva*
• Keywords: Adsorption, Calcium Chloride, Chlorhexidine, Hydroxyapatite, Zinc Chloride, Zinc Oxide

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