Properties Alteration of Anti-Tuberculosis Drugs Loaded 3D Printed Hydroxyapatite by Polycaprolactone Coating

Abstract:

Anti-tuberculosis drugs loaded three dimensionally printed hydroxyapatite (3D printed HA) were prepared and coated with polycaprolactone to study the effect of coating on compressive resistance, microstructure, drug content and releasing characteristics. Smooth coating layer was observed on the surfaces of all coated samples while the uncoated samples displayed rough and porous surfaces. Coated samples had greater compressive resistance than uncoated samples, but the total drug contents in coated samples were slightly lower than those of uncoated ones. Both coated and uncoated samples displayed burst release of drugs initially and followed by a small release afterward. Polycaprolactone coating greatly decrease the amount of burst release of rifampicin drug loaded samples, but slightly decrease in the case of isoniazid drug loaded samples. Higher solubility of isoniazid than rifampicin in release media was thought to be the cause of limited efficiency of coating as observed.

• Periodical: Key Engineering Materials (Volume 766)
• Pages: 94-98
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.766.94
• Online since: April 2018
• Authors: Waraporn Suvannapruk, Jintamai Suwanprateeb*
• Keywords: Bone Tuberculosis, Coating, Drug Impregnation, Hydroxyapatite, Polycaprolactone

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