For Libraries For Publication Open Access Downloads About Us Contact Us
Paper Titles
Revisiting the Deshpande-Fleck Foam Model
p.134
Effect of Sintering Holding Time on Tetragonal Phase Stability of Yttria Stabilized Zirconia Ceramics
p.143
Influence of Fine Shot Peening on Mechanical Properties of Orthopedic Plate and Screw
p.148
Rice Starch–Based Sponge for Use as Topical Hemostatic Agent
p.153
Nano-Delivery Materials: Review of Development and Application in Drug/Gene Transport
p.158
Influence of Third Element of TiNi Alloy on Tribological Behavior in Dry and Wet Conditions for Orthodontic Applications
p.167
Preparation of pH-Responsive Nanoparticles (PRNPs) for Detection of Pathogenic Escherichia coli from Stool Sample of Diarrheagenic Patients
p.172
Compressive Property and Electrochemistry Behavior of Porous Ti-Nb-Ta-Zr for Biomedical Applications
p.178
Water Adsorption Properties of Titanium(IV) Oxide Embedded in Multiwalled Carbon Nanotubes (CNT)
p.182

Nano-Delivery Materials: Review of Development and Application in Drug/Gene Transport

Article Preview

Abstract:

As the nanotechnology rapidly develops, the combination of nanotechnology and biotechnology to build nanoparticles with biological functionalization has brought new opportunities for the development and application of biomedical diagnosis. Many new non-viral drug/gene vectors were constructed by using nanoparticles as drug/gene carriers, especially by making conventional inorganic materials into nanoparticles and performing functional modifications. In this paper, the physical and chemical properties, preparation methods and application in drug/gene transport of several nanomaterials including mesoporous silica nanoparticles, gold nanoparticles, dendrimers, graphene oxide and carbon nanotubes are reviewed respectively. At the same time, the merit and dismerit of different nanocarriers and their application scenarios are compared. It has been found that the excellent biocompatibility and large specific surface area of inorganic nanomaterials have great potential for drug/gene delivery. Although there are many bottlenecks and challenges for nanomaterials to settle during drug delivery development and industrial production, the improvement of inorganic nanomaterials and the development of new nanocarriers can promote the wider progress of nanocarriers in drug/gene transport.

You might also be interested in these eBooks
Advanced Materials Research IX View Preview

Info:

Periodical:

Key Engineering Materials (Volume 803)

Pages:

158-166

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.803.158

Citation:

Cite this paper

Online since:

May 2019

Authors:

Yu Lin Li*, Bin Huan Sun

Keywords:

Carbon Nanotubes, Dendrimer, Drug Delivery, Functional Nanoparticles, Nanoparticle Carrier

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2019 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

* - Corresponding Author

References

[1] Ma X Y and Chen H B: China Medical Herald. Vo32. 13-15 (2006).

Google Scholar

[2] Fan D H, Dai H L, Liu Y and Wei R M: Journal of wuhan university of technology. Vo4. 109-111 (1995).

Google Scholar

[3] Birrenbach, G. and Speiser, P. P: Pharm. Sci. Vo65. 1763-1766 (1976).

Google Scholar

[4] Yang T Y, Pan W S and Hu J: World Pharmac. Vo4. 222-225 (1991).

Google Scholar

[5] Xu Z P, Zeng Q H, Lu G Q and et al.: Inorganic nanoparticles as carriers for efficient cellular delivery (Chemical Engineering Science, China, 2006).

Google Scholar

[6] Xiaohong Jin, in: Mesoporous Silica: Synthesis, Morphology control, Assembly, and Property. Zhejiang University published, (2005).

Google Scholar

[7] Kresge, C. T., Leonowicz, M. E. and et al.: Nature. Vo359. 710-712 (1992).

Google Scholar

[8] Yang N, Zhu S M, and Zhang D: Chinese Journal of Inorganic Chemistry. Vo9. 1627-1630 (2007).

Google Scholar

[9] Zhang L, Wang X, Xue Y and et al.: Catalysis Science & Technology. Vo4. 1939-1948 (2004).

Google Scholar

[10] Hou G H, Luo J H and Chen J W: Journal of Materials Science and Engineering. Vo4. 528-530 (2006).

Google Scholar

[11] Ma X H, Zhao Y B and et al.: ACTA PHYSICO-CHIMICA SINICA. Vo3. 492-496 (2008).

Google Scholar

[12] Jin X T, Liu G, Li J Z, et al: Chemical Journal of Chinese Universities. Vo37. 224-231(2016).

Google Scholar

[13] Rashid, M. H, Bhattacharjee, R. R, Kotal, A. and Mandal, T. K: Langmuir. Vo22. 7141-7143 (2006).

Google Scholar

[14] Daniel, M. C., Astruc, D: Chemical Reviews. Vo104. 293-346 (2004).

Google Scholar

[15] Sun S J and Jiang Z L: Precious Metals. Vo26. 55-65 (2005).

Google Scholar

[16] Yuan S, Liu Z and Ma S.: Materials Review. Vo26. 52-58 (2012).

Google Scholar

[17] Tiwari, P. M., Vig, K., Dennis, V. A. and et al.: Nanomaterials. Vo1. 31-63 (2011).

Google Scholar

[18] FRENS, G: Nature Physical Science. Vo241. 20-22 (1973).

Google Scholar

[19] Martin, C. R.: Science. Vo266. 1961-1966 (1994).

Google Scholar

[20] Wang C R, Fang Y and Feng J W: ACTA CHIMICA SINICA. Vo65. 1177-1180 (2007).

Google Scholar

[21] Z. WangY.-K. and SuH.-L. Li.: APPl Phys A. Vo74. 563-565 (2002).

Google Scholar

[22] S Chah, J H Fendler and J Yi: Journal of Colloid and Interface Science. Vo250. 142-148 (2002).

Google Scholar

[23] Zhu Z H, Zhu T and Liu Z F: ACTA PHYSICO-CHIMICA SINICA. Vo15. 966-970 (1999).

Google Scholar

[24] Wang P B, in: Preparation and characterization of controllable gold nanoparticles. Lanzhou University Of Technology published, (2009).

Google Scholar

[25] Wang H J, Xue C Y and Yuan Y L: Chinese Journal of Sensors and Actuators. Vo24. 14-17 (2011).

Google Scholar

[26] Sau, Tapan K, Murphy and Catherine J: Am. Chem. Vo126. 8648-8649 (2004).

Google Scholar

[27] Zhu J, Wang Y C and Wang Q: ACTA PHOTONICA SINICA. Vo32. P.58 (2003).

Google Scholar

[28] Shen L M, Yao J L and Gu R A: Spectroscopy and Spectral Analysis. Vo12. 1998-2001 (2005).

Google Scholar

[29] Feng X L, in: Mechanism study of electrochemical synthesis of gold nanoparticles and phase transfer technology of precious metal nanoparticles. Shangdong University published, (2007).

Google Scholar

[30] Wen L, in: Synthesis, Characterization and Applications of Au Clusters and Nanoparticles. Xiamen University pulished, (2008).

Google Scholar

[31] Wu S M, Su Y L and Ma L Y: Microbiology. Vo41. 2516-2524 (2014).

Google Scholar

[32] Hou Z S, Zhang Q Z and Zhu M G: Shandong Chemical Lndustry. Vo2. 10-12 (2012).

Google Scholar

[33] Liu X X, in: Structurally flexible PAMAM dendrimers as novel nanovectors for nucleic acid delivery. Wuhan University published, (2010).

Google Scholar

[34] Wang G, Luo Y J and Tan H M: Polymer materials and engineering. Vo5. 1-6 (2002).

Google Scholar

[35] Sun W Y, in: Synthesis characterization and properties of functional carbosilane dendrimer. Shandong University published, (2009).

Google Scholar

[36] Xu P, in: Preparation of PAMAM Dendrimer Nano Assembly System and its Application in Gene Delivery. Shanghai Jiaotong University published, (2007).

Google Scholar

[37] Buhleier E, Wehner W and Vogtle F: Synthesis Vo155. (1978).

Google Scholar

[38] Lothian-Tomalia M K, Hedstrand D M and et al.: Tetrahedron. Vo53. 15495-15513 (1997).

Google Scholar

[39] Zhao H: Journal of Zhongzhou University. Vo1. 103-105 (2004).

Google Scholar

[40] Ajayan, P. M: Chemical Reviews. Vo99. 1787-1800 (1997).

Google Scholar

[41] Raymond M Reilly: Journal of Nuclear Medicine. Vo48. 1039-1042 (2007).

Google Scholar

[42] Alberto Bianco and Kostas Kostarelos: Current Opinion in Chemical Biology. Vo9. 674-679 (2005).

Google Scholar

[43] Deng Y, Huang X R and Wu X L: Material Review. Vo26. 84-87 (2012).

Google Scholar

[44] Matsuo Y and Sugie Y: Carbon. Vo36. 301-303 (1998).

Google Scholar

[45] Staudenmaier L: European Journal of Inorganic Chemistry. Vo32. 1394-1399 (2010).

Google Scholar

[46] Hummers W S and Offeman R E: Journal of the American Chemical Society. Vo80.1339-1339 (1958).

Google Scholar

[47] Li J H, Kuang D Z, Feng Y L and et al.: Chinese Journal of Analytical Chemistry. Vo41. 98-104 (2013).

Google Scholar

[48] Zhao Q P, Yang C, Li X R, Song G J and Cong L L: Journal of Bohai University (Natural Science Edition). Vo36. 333-336 (2015).

Google Scholar

[49] Lai, C. Y.; Trewyn, B. G; Jeftinija and et al.: Am. Chem. Soc. Vo125, P. 4451 (2003).

Google Scholar

[50] Giri, S.; Trewyn, B. G; Stellmaker, M. P. and et al.: Angew. Chem., Int. Ed. Vo44, P. 5038 (2005).

Google Scholar

[51] Lai C Y, Trewyn B G, Jeftinija D M and et al.: American Chemical Society. Journal. Vo125. 4451-4459 (2003).

Google Scholar

[52] Zhu C L, Song X Y and et al.: Journal of Materials Chemistry. Vo19. 7765-7770 (2009).

Google Scholar

[53] Yehui Wu, Yuzhi Chen and et al.: Sensors & Actuators: B. Chemical. Vo270. 443-451 (2018).

Google Scholar

[54] Y.M. Narode, V.M. Mokashi, and G.K. Sharma: Journal of Luminescence. Vo201. 479-484 (2018).

Google Scholar

[55] An X Q, Zhan F and Zhu Y Y: Langmuir. Vo29. 1061-1068 (2013).

Google Scholar

[56] Bianco, A., Kostarelos, K. and Prato, M.: Expert Opin Drug Deliv. Vo5. 331-342 (2008).

Google Scholar

[57] Pan B F, Cui D X, Xu P and et al.: Chinese Journal of Cancer Biotherapy. Vo3. 176-180 (2006).

Google Scholar

[58] Giri, S. Trewyn,B. G; Stellmaker, M. P., and Lin, V. S. Y: Angew. Chem., Int. Ed. Vo44. P. 5038 (2005).

Google Scholar

© 2025 Trans Tech Publications Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For open access content, terms of the Creative Commons licensing CC-BY are applied.
Scientific.Net is a registered trademark of Trans Tech Publications Ltd.