Matrix Forming Behavior of Doxycycline Hyclate-Loaded Beta-Cyclodextrin In Situ Forming Matrix and Microparticle

Nutdanai Lertsuphotvanit; PORNSIT CHAIYA; Thawatchai Phaechamud

doi:10.4028/www.scientific.net/KEM.819.221

Paper Titles

Mixed Solvent-Lauric Acid Solvent-Exchange Induced In Situ Forming Gel
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Alpha-Mangostin Phase Inversion Induced In Situ Forming Gel
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Characterization of Lauric Acid Precipitated from Biocompatible Solvents
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Gamboge Resin-Based Phase Separation In Situ Forming Gel
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Matrix Forming Behavior of Doxycycline Hyclate-Loaded Beta-Cyclodextrin In Situ Forming Matrix and Microparticle
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Application of Simplex Lattice Design in Formulation Development of Lozenges Containing Vernonia cinerea Extract for Smoking Cessation
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Development and Evaluation of Acetaminophen Orodispersible Disc with Taste-Masking Property
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HomeKey Engineering MaterialsKey Engineering Materials Vol. 819Matrix Forming Behavior of Doxycycline...

Matrix Forming Behavior of Doxycycline Hyclate-Loaded Beta-Cyclodextrin In Situ Forming Matrix and Microparticle

Abstract:

In situ forming microparticle (ISM) is an injectable emulsion drug delivery system comprising drug loaded in polymeric solution as internal phase and oil combined with emulsifier as external phase. This emulsion transforms into microparticle after contact an aqueous environment by solvent exchange mechanism. This study developed ISM using internal phase comprising 5% w/w doxycycline hyclate (DH) loaded with various concentrations of beta-cyclodextrin (β-CD) using N-methyl-2-pyrrolidone (NMP) as a solvent and external phase containing olive oil combined with glyceryl monostearate (GMS). High concentrated β-CD solutions in NMP are used as the internal phase of ISM. Matrix forming behavior is evaluated for their particle size, transformation to microparticle, pH, rate of matrix formation, contact angle and surface tension. Each emulsion had similar pH values about 3.5-4.1 and transformed into microparticles (particle size about 60 μm) after contact with phosphate buffer pH 6.8. The particle sizes of each preparation decreased significantly after transformed into microparticles and the more microparticles were evident with time. The rate of matrix formation of ISM was apparent slower than its internal phase and was slower with time. Contact angle of ISM and its internal phase showed good wetting which the surface tension of 35% w/w β-CD ISM was 44.19 mN/m. The β-CD ISM exhibited as the potential delivery system for incorporation of active compounds.

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Key Engineering Materials (Volume 819)

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221-226

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https://doi.org/10.4028/www.scientific.net/KEM.819.221

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August 2019

Authors:

Nutdanai Lertsuphotvanit, PORNSIT CHAIYA, Thawatchai Phaechamud*

Keywords:

Beta-Cyclodextrin, Doxycycline Hyclate, In Situ Forming Matrix, In Situ Microparticles

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