Development and Evaluation of Acetaminophen Orodispersible Disc with Taste-Masking Property

Phirawat Trirattanapintusorn; Sirachai Leatpianpanit; Phurit Thanarangsarit; Srisagul Sungthongjeen; Worawut Kriangkrai

doi:10.4028/www.scientific.net/KEM.819.233

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HomeKey Engineering MaterialsKey Engineering Materials Vol. 819Development and Evaluation of Acetaminophen...

Development and Evaluation of Acetaminophen Orodispersible Disc with Taste-Masking Property

Abstract:

Orodispersible tablet (ODT) provides rapid disintegration in the oral cavity. ODT improves the efficacy of using medicines especially in term of compliance in a patient with dysphagia. The major challenge of ODT is a bitter taste of active pharmaceutical ingredient (API); they can lead the patients to refuse medication. This study focused on the developing of the orodispersible disc (ODD) with a taste masking property by preparation of API particle that was taste-masked by polymers. The co-precipitation technique was used for the taste masking. Acetaminophen (APAP) taste-masked particles prepared with different grades of crospovidone were investigated for the taste-masking property. Kollidon^® CL-SF exhibited the lowest drug release. An increasing amount of Kollidon^® CL-SF caused increasing of APAP release. Particles consisted of APAP:crospovidone at ratio 3:1 showed the lowest drug release. It was probably due to the complexation which was shown by the FT-IR and DSC. Taste-masked particles were compressed as ODD by a hydraulic press machine. The disintegrating time of ODD was at the range of 12.62-17.35 s. The dissolution of ODD was focused on the taste-masking zone (drug release in 1 min). The ODD with ratio 3:1 particle (APAP: Kollidon^® CL-SF) showed the highest taste-masking performance, the lowest drug release. All disc formulations completely released APAP after 30 min. Therefore, the preparation of ODD contains taste-masked particles was promising to improve patient compliance of bitter APIs.

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Periodical:

Key Engineering Materials (Volume 819)

Pages:

233-239

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.819.233

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Online since:

August 2019

Authors:

Phirawat Trirattanapintusorn, Sirachai Leatpianpanit, Phurit Thanarangsarit, Srisagul Sungthongjeen, Worawut Kriangkrai*

Keywords:

Acetaminophen, Co-Precipitation Technique, Crospovidone, Orodispersible Tablet, Taste-Masking Property

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