Effect of Formulations and Spray Drying Process Conditions on Physical Properties of Resveratrol Spray-Dried Emulsions

Abstract:

Spray-dried emulsion is one of the useful strategies to enhance dissolution properties of poorly water-soluble drug for example resveratrol. Physical properties i.e. particle size and moisture content of spray-dried emulsions could affect their quality attributes. In this study, Box-Behnken design was performed in order to determine effect of formulation and spray drying condition parameters i.e. feed rate on responses including particle size and moisture content of resveratrol spray-dried emulsions. The spray-dried emulsions were prepared by varying content of low-methoxyl pectin (LMP) and caprylic/capric glycerides (CCG) and sprayed at different feed rate. Box-Behnken design results reveled that the particle size of spray-dried emulsions was significantly influenced by the content of LMP, interactions between LMP and CCG, interactions between LMP and feed rate. LMP content showed positive relationships with the particle size. The content of CCG had negative significantly effect on moisture content of the spray-dried emulsion. Mathematical models describing the relationships between studied parameters and responses provided good predictability. Based on model, the optimal formulation was prepared using 2.6% w/w of LMP, 9% w/w of CCG, and feed rate of 6.8 mL/min and the small particle size (~5.9 μm) and low moisture content (~5.6%) were obtained. The spray-dried emulsions were successfully prepared with satisfy quality. The Box-Behnken design would be an effective tool to elucidate influence of formulation and spray drying conditions on particle size and moisture content of the spray-dried emulsions. Further, the design aided in developing and optimizing the spray-dried emulsions with specified quality.

• Periodical: Key Engineering Materials (Volume 819)
• Pages: 246-251
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.819.246
• Online since: August 2019
• Authors: Pontip Benjasirimongkol, Suchada Piriyaprasarth, Pornsak Sriamornsak*
• Keywords: Box-Behnken Design, Optimization, Resveratrol, Spray-Dried Emulsion

References

[1] Kalepu S, Nekkanti V. Insoluble drug delivery strategies: review of recent advances and business prospects. Acta Pharm Sin B 2015;5:442–53.

DOI: 10.1016/j.apsb.2015.07.003

[2] Pongsamart K, Kleinebudde P, Puttipipatkhachorn S. Preparation of fenofibrate dry emulsion and dry suspension using octenyl succinic anhydride starch as emulsifying agent and solid carrier. Int J Pharm 2016;498:347–54.

DOI: 10.1016/j.ijpharm.2015.12.041

[3] Benjasirimongkol P, Piriyaprasarth S, Sriamornsak P. Improving dissolution and photostability of resveratrol using redispersible dry emulsion: Application of design space for optimizing formulation and spray-drying process. J Drug Deliv Sci Technol 2019;51:411-418.

DOI: 10.1016/j.jddst.2019.03.005

[4] Benjasirimongkol P, Piriyaprasarth S, Moribe K, Sriamornsak P. Use of risk assessment and Plackett–Burman design for developing resveratrol spray-dried emulsions: A quality-by-design approach. AAPS PharmSciTech 2019;20:Article 14.

DOI: 10.1208/s12249-018-1220-z

[5] Cal K, Sollohub K. Spray drying technique. I: Hardware and process parameters. J Pharm Sci 2010;99:575–86.

DOI: 10.1002/jps.21886

[6] Elversson J, Millqvist-Fureby A. Particle size and density in spray drying—Effects of carbohydrate properties. J Pharm Sci 2005;94:2049–60.

DOI: 10.1002/jps.20418

[7] Botrel DA, Borges SV, Fernandes RVDB, Carmo EL Do. Optimization of fish oil spray drying using a protein:inulin system. Dry Technol 2014;32:279–90.

DOI: 10.1080/07373937.2013.823621

[8] Choi G, Le T-H, Shin S. A new multidimensional design space identification method for a quality-oriented drug development process. Total Qual Manag Bus Excell 2016;27:804–17.

DOI: 10.1080/14783363.2016.1187999