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HomeKey Engineering MaterialsKey Engineering Materials Vol. 840Synthesis N-Phenyl Pyrazoline from Dibenzalacetone...

Synthesis N-Phenyl Pyrazoline from Dibenzalacetone and Heme Polymeration Inhibitory Activity (HPIA) Assay

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Abstract:

The synthesis of 1,5-diphenyl-3-styryl-4,5-dihydro-1H-pyrazole (B1) and 5-(3,4-dimethoxyphenyl)-3-(3,4-dimethoxystyryl)-1-phenyl-4,5-dihydro-1H-pyrazole (B2) have been conducted from 1,5-diphenylpenta-1,4-dien-3-on (A1) and 1,5-bis(3,4-dimethoxyphenyl)penta-1,4-dien-3-one (A2). Heme polymerization inhibitory activity (HPIA) assay of the synthesized compounds has also been carried out. The first step of reaction was Claisen-Schmidt condensation of benzaldehyde derivatives and acetone using NaOH 20% and ethanol as solvent. Dibenzalacetone derivatives were reacted with phenylhydrazine using acetic acid to form N-phenylpyrazoline. The structure of products was characterized by FT-IR, GC-MS, DI-MS, ¹H- and ¹³C-NMR The result of heme polymerization inhibitory activity assay showed that IC₅₀of B1 and B2 1.26 and 0.79 mM while quinine 1.26 mM. The result indicated that compound B2 was more potent as antimalarial than quinine.

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Symposium of Materials Science and Chemistry II

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Periodical:

Key Engineering Materials (Volume 840)

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245-250

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.840.245

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Online since:

April 2020

Authors:

Linda Ekawati*, Bambang Purwono, Muhammad Idham Darussalam Mardjan

Keywords:

Dibenzalacetone, HPIA, N-Phenyl Pyrazoline

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© 2020 Trans Tech Publications Ltd. All Rights Reserved

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