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HomeKey Engineering MaterialsKey Engineering Materials Vol. 840Synthesis, Characterization, and Antibacterial...

Synthesis, Characterization, and Antibacterial Evaluation of Curcumin-Sulfanilamide Compound

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Abstract:

Curcumin, a diarylheptanoids compound which isolated primary from Curcuma longa, exhibits a variety of exciting biological activities, including as an antibacterial agent. In the present study, a sulfanilamide-contained curcumin compound was synthesized and characterized to investigate the antibacterial activity against gram-positive bacteria S. aureus, B. subtilis and gram-negative bacteria E. coli. The characterization of the synthesized compound was determined by analysing peak absorbance, functional group, and molecular weight using mass spectroscopy, UV/Vis and FTIR spectrophotometry. Curcumin-sulfanilamide compound exhibited the best antibacterial activity against gram-negative bacteria compared to curcumin and the curcumin-derived compound containing isoxazole with inhibitory zone of 11 mm.

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Symposium of Materials Science and Chemistry II

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Periodical:

Key Engineering Materials (Volume 840)

Pages:

265-269

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.840.265

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Online since:

April 2020

Authors:

Nurjanah Nurjanah*, Endang Saepudin

Keywords:

Antibacterial, Curcumin, Curcumin-Isoxazole, Curcumin-Sulfanilamide

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© 2020 Trans Tech Publications Ltd. All Rights Reserved

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[1] FAO, Production share of spices nes by region FAOSTA, (2016).

[2] E.T. Jessica, F. Gassara, A.P. Kouassi, S.K. Brar, K.Belkacemi, Spice use in food: properties and benefits, Crit. Rev. Food Sci. Nutr. 57 (2017) 1078-1088.

DOI: 10.1080/10408398.2013.858235

[3] C. Changtam, P. Hongmanee, A. Suksamrarn, Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity, Eur. J. Med. Chem. 45 (2010) 4446–4457.

DOI: 10.1016/j.ejmech.2010.07.003

[4] O.A. Hamed, N. Mehdawi, A.A. Taha, E.M. Hamed, M.A. Al-Nuri, A.S. Hussein, Synthesis and antibacterial activity of novel curcumin derivatives containing heterocyclic moiety, Iran. J. Pharm. Res. 12 (2013) 47–56.

[5] A. Amalraj, A. Pius, S. Gopi, S. Gopi, Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives–a review, J. Tradit. Complement. Med. 7 (2016) 205–233.

DOI: 10.1016/j.jtcme.2016.05.005

[6] K.M. Nelson, J.L. Dahlin, J. Bisson, J. Graham, G.F. Pauli, M.A. Walters, The essential medicinal chemistry of curcumin, J. Med. Chem. 60 (2017) 1620–1637.

DOI: 10.1021/acs.jmedchem.6b00975

[7] M. Ahmed, M.A. Qadir, A. Hameed, M.N. Arshad, A.M. Asiri, M. Muddassar, Sulfonamides containing curcumin scaffold: synthesis, characterization, carbonic anhydrase inhibition and molecular docking studies, Bioorg. Chem. 76 (2018) 218–227.

DOI: 10.1016/j.bioorg.2017.11.015

[8] H. Gaffer, H.M. Mashaly, S. Hassan, Synthesis of novel dyes based on curcumin for the creation of antibacterial silk fabrics, Pigm. Resin Technol. 46 (2016) 1–4.

DOI: 10.1108/prt-11-2016-0112

[9] G. Banuppriya, R. Sribalan, V. Padmini, Synthesis and characterization of curcumin-sulfonamide hybrids: biological evaluation and molecular docking studies, J. Mol. Struct. 1155 (2018) 90–100.

DOI: 10.1016/j.molstruc.2017.10.097

[10] J. Lal, S.K. Gupta, D. Thavaselvam, D.D. Agarwal, Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides, Eur. J. Med. Chem. 64 (2013) 579–588.

DOI: 10.1016/j.ejmech.2013.03.012

[11] G.A. Elmegeed, H.H. Ahmed, M.A. Hashash, M.M. Abd-Elhalim, D.S. El-Kady, Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer's disease candidates: evidences-based on in vivo study, Steroids. 101 (2015) 78–89.

DOI: 10.1016/j.steroids.2015.06.003

[12] C. Changtam, H.P. de Koning, H. Ibrahim, M.S. Sajid, M.K. Gould, A. Suksamrarn, Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species, Eur. J. Med. Chem. 45 (2010) 941–56.

DOI: 10.1016/j.ejmech.2009.11.035

[13] G.T. Solomons, C.B. Fryhle, Organic Chemistry, Tenth ed., John Wiley & Sons, Hoboken, (2011).

[14] M. Balouiri, M. Sadiki, S.K. Ibnsouda, Methods for in vitro evaluating antimicrobial activity: a review, J. Pharm. Anal. 136 (2016) 71-79.

DOI: 10.1016/j.jpha.2015.11.005

[15] J.A. Washington, P.K. Yu, T.L. Gavan, F.D. Schoenknecht, C. Thornsberry, Interpretation of the disk diffusion susceptibility test for amikacin : report of a collaborative study, Antimicrob. Agents Chemother. 15 (1979) 400–407.

DOI: 10.1128/aac.15.3.400

[16] I. Aibinu, E. Aednipekun, T. Odugbemi, Emergence of quinolone resistance amongst Escherichia coli strains isolated from clinical infections insome Lagos Sate Hospitals in Nigeria, Niger. J. Health Biomed. Sci. 2 (2004) 73–78.

DOI: 10.4314/njhbs.v3i2.11513