Characterization of Rheological Property of Mucoadhesive Polymeric Sol-Gel in the Presence of Black Ginger Kaempferia parviflora Extract

Abstract:

The local drug delivery based on mucoadhesion is an effective medical treatment. The mucoadhesive property relies on the formulated gel having optimized rheology. The addition of the drug also showed a major influence towards the sol-gel transition. In this study, compositional effect of Eudragit E100^® base polymer, various mucoadhesive polymers, and the black ginger extract on the rheological property of the formulated sol-gel was assessed. It was found that gelling point and gel strength could be tuned mainly based on the concentration of Eudragit E100 limited at 40% w/w due to the viscosity. At Eudragit E100 of 30% w/w, 0.5% w/w herbal extract, and 1%w/w polyvinyl alcohol, the solution reached the gel point at 286 s (tan δ=1) with the gel strength of 1 kPa (G’=G”). For all the formulated sol-gels, the rheological property became better (faster gelling point with the gel strength varying from 100-700 kPa at low strain) a simulated saliva environment.

• Periodical: Key Engineering Materials (Volume 859)
• Pages: 81-86
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.859.81
• Online since: August 2020
• Authors: Siriporn Taokaew, Nattanich Wattanaphraya, Worawut Kriangkrai*
• Keywords: Gel Point, Kaempferia parviflora, Mucoadhesion, Rheological Property, Sol-Gel Transition

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