Xanthan Gum-Incorporated Natural Rubber Film Casted with Solvent Evaporation

Abstract:

Xanthan gum (X)-incorporated natural rubber (NR) cast films were fabricated from blocked NR by solvent casting method using dichloromethane as the solvent. The rather smooth films were obtained. X markedly promoted both of water sorption and erosion in phosphate buffer pH 7.4 of these composite films. With increasing X amount also significantly enhanced the film tensile strength, Young’s modulus and area under the curve while did not affect contact angle of water/formamide and surface free energy. 30%X-loaded NR films exhibited the highest durability with apparently high water sorption and erosion for further using such as wound dressing.

• Periodical: Key Engineering Materials (Volume 859)
• Pages: 68-73
• DOI: https://doi.org/10.4028/www.scientific.net/KEM.859.68
• Online since: August 2020
• Authors: Napaphol Puyathorn, Thawatchai Phaechamud*
• Keywords: Casted Film, Natural Rubber, Solvent Evaporation, Xanthan Gum

References

[1] A. Alhalmi, N. Alzubaidi, M. Altowairi, M. Almoiliqy, B. Sharma, Xanthan gum; its biopharmaceutical applications: An overview, Word J. Biopharm. Appl. Sci. 7 (2018) 1536-1548.

[2] U. Mikac, A. Sepe, A. Gradišek, J. Kristl, T. Apih, Dynamics of water and xanthan chains in hydrogels studied by NMR relaxometry and their influence on drug release, Int. J. Pharm. 563 (2019) 373-383.

DOI: 10.1016/j.ijpharm.2019.04.014

[3] C.R. Park, D.L. Munday, Evaluation of selected polysaccharide excipients in buccoadhesive tablets for sustained release of nicotine, Drug Dev. Indus. Pharm. 30 (2004) 609–617.

DOI: 10.1081/ddc-120037492

[4] X. Cai, P. Mesquida, S. Jones, Investigating the ability of nanoparticle-loaded hydroxypropyl methylcellulose and xanthan gum gels to enhance drug penetration into the skin, Int. J. Pharm. 513 (2016) 302-308.

DOI: 10.1016/j.ijpharm.2016.08.055

[5] J. Suksaeree, P. Boonme, W. Taweepreda, G.C. Ritthidej, W. Pichayakorn, Characterization, in vitro release and permeation studies of nicotinetransdermal patches prepared from deproteinized natural rubberlatex blends. Chem.Eng. Res. Des. 90 (2012) 906-914.

DOI: 10.1016/j.cherd.2011.11.002

[6] W. Pichayakorn, J. Suksaeree, P. Boonme, T. Amnuaikit, W. Taweepreda, G.C. Ritthidej, Nicotine transdermal patches using polymeric natural rubber as the matrix controlling system: effect of polymer and plasticizer blends, J. Membr. Sci. 411-412 (2012) 81-90.

DOI: 10.1016/j.memsci.2012.04.017

[7] T. Phaechamud, N. Lertsuphotvanit, P. Issarayungyuen, T. Chantadee. Design, fabrication and characterization of xanthan gum/liquidloaded porous natural rubber film, J. Pharm. Invest. 2019;49(1):49:149-160. DOI 10.1007/s40005-018-0396-2.

DOI: 10.1007/s40005-018-0396-2

[8] S. Wu, K.J. Brzozowski, Surface free energy and polarity of organic pigments, J. Colloid Interface Sci. 37 (1971) 686–690.

DOI: 10.1016/0021-9797(71)90347-x

[9] ASTM International. Standard Test Methods for Vulcanized Rubber and Thermoplastic Elastomers-Tension D412. ASTM: West Conshohocken, PA, USA, 2003; Vol. 9.

[10] A. Sorsom, Development of pressure sensitive adhesive patch from natural rubber. MScience dissertation, Faculty of Science, Graduate School, Prince of Songkla University, (2009).

[11] A.R. Dezfuli, A.S. Aravindram, M. Manjunath, N.S. Genesh, T. Shailesh, Development and evaluation of transdermal films loaded with antihypertensive drug, Int. J. Pharm. Bio. Sci. 3 (2012) 559–569.

[12] T.Phaechamud, P. Issarayungyuen, W. Pichayakorn, Gentamicin sulfate-loaded porous natural rubber films for wound dressing, Int. J. Biol. Macromol. 85 (2016) 634-644.

DOI: 10.1016/j.ijbiomac.2016.01.040