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HomeKey Engineering MaterialsKey Engineering Materials Vol. 859In Vitro and In Vivo Evaluation of Amphiphilic...

In Vitro and In Vivo Evaluation of Amphiphilic Chitosan Derivatives for Inhibition of Organic Cation Transport Function

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Abstract:

This study explored the interaction of amphiphilic chitosan derivatives, N-benzyl-N,O-succinyl chitosan (BSCS), N-naphthyl-N,O-succinyl chitosan (NSCS) and N-octyl-N,O-succinyl chitosan (OSCS), with renal organic cation transporter 2 (OCT2). The influence of amphiphilic chitosan derivatives on renal OCT2 transport function was determined by monitoring the transport of a positively charged substrate into human renal proximal tubular epithelial cells (RPTEC/TERT1 cells), and murine kidney. Amphiphilic chitosan derivatives inhibited 3H-MPP (a substrate of OCT2) transport in the renal cells in a concentration-reliance characteristic. OSCS reduced the accumulation of the cationic drug, cisplatin, in RPTEC/TERT1 cells. This effect was more pronounced than that of other chitosan derivatives. In addition, co-administration of cisplatin and OSCS significantly reduced cisplatin accumulation compared with receiving cisplatin alone. This result was accompanied by the decrease in nephrotoxicity induced by cisplatin. In conclusion, OSCS inhibited OCT2 function and reduced cationic drug disposition in human renal proximal tubular cells and murine kidney.

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Pharmaceutical and Biomedical Materials and Technology II

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Periodical:

Key Engineering Materials (Volume 859)

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45-50

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.859.45

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Online since:

August 2020

Authors:

Sirima Soodvilai*, Sunhapas Soodvila, Warayuth Sajomsang, Theerasak Rojanarata, Prasopchai Patrojanasophon, Praneet Opanasopit

Keywords:

Amphiphilic Chitosan Derivatives, Cisplatin, Drug Transport, Kidney

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© 2020 Trans Tech Publications Ltd. All Rights Reserved

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* - Corresponding Author

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