Hybrid Gelatin/Carboxymethyl Cellulose Hydrogel Loaded Copper (II) Ion for Medical Applications

Abstract:

Antibacterial wound dressing has an important key in an infection in traumatic and surgical wounds. However, the antibacterial wound dressing is high cost and few domestic medical productions. The aim of this study is to prepare a wound dressing hydrogel from hybrid gelatin/carboxymethyl cellulose (Gel/CMC) hydrogel crosslinked with citric acid at different Gel: CMC ratios of 1:1, 1:2, 1:3, and 1:4 by solvent casting. The gel fractions and swelling of 6.0%w/v CuSO₄ loading hybrid Gel/CMC hydrogel (Cu-Gel/CMC hydrogel) were a maximum of about 44% to 53% and 85% to 245%, respectively. The results showed that the 1:1 Gel: CMC of hydrogel produce was the most suitable condition due to its good gel fractions and swelling behavior. The cumulative Cu²⁺ release was a maximum of about 45% in 7 days. The hybrid Cu-Gel/CMC hydrogel showed the zone of inhibition of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) about 16 mm and 19 mm, sequentially. The research provided that the hybrid Cu-Gel/CMC hydrogel has the potential to use in medical applications.

• Periodical: Materials Science Forum (Volume 1009)
• Pages: 3-8
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.1009.3
• Online since: August 2020
• Authors: Narumol Kreua-Ongarjnukool*, Saowapa Thumsing Niyomthai, Kodchaporn Sarodom, Thitithip Lothong, Nopparuj Soomherun
• Keywords: Antibacterial, Carboxymethyl Cellulose, Gelatin, Hydrogel, Wound Dressing

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