Synthesis and Characterization of 50S8P Bioglass through Sol Gel Method

Abstract:

Bioactive glasses (BG) were applied in bone and dental applications as well as in tissue engineering. In this studies, a new bioglass 50S8P (50% SiO₂, 22% CaO, 20% Na₂O and 8% P₂O₅) with different aging time (3, 7, 10 and 15 days) was prepared by sol-gel method. These synthesized glasses were analyzed using X- ray powder diffraction (XRD), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The bioactivity of all BG is evaluated by incubating the BG powder in Hank's Balanced Salt Solution (HBSS) for 7, 14 and 21 days. Thermal analyses indicated the compositions can be stabilized at 700°C. XRD confirmed the primary crystalline phase was Na₄Ca₄Si₆O₁₈. Formation of silica network is established with the existence of functional group Si-O-Si (tetrahedral), confirmed with FTIR analyses. In vitro test confirm the apatite formation on the BG surface with characteristic of carbonate group (C-O) and P-O band noticed from FTIR and morphology of apatite formation on BG surface was observe using SEM

• Periodical: Materials Science Forum (Volume 1010)
• Pages: 626-631
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.1010.626
• Online since: September 2020
• Authors: Sharifah Aishah Syed Salim, Hasmaliza Mohamad*, Siti Noor Fazliah Mohd Noor
• Keywords: Bioactive Glass, Bioactivity, Sol Gel

References

[1] N. Farhana, H. Mohamad, S. Noor, F. Mohd, and N. Ahmad, Apatite formation on melt-derived bioactive glass powder based,, Ceram. Int., vol. 43, no. 15, p.11676–11685, (2017).

DOI: 10.1016/j.ceramint.2017.05.356

[2] A. Lucas-Girot, F. Z. Mezahi, M. Mami, H. Oudadesse, A. Harabi, and M. Le Floch, Sol-gel synthesis of a new composition of bioactive glass in the quaternary system SiO2-CaO-Na2O-P2O5: Comparison with melting method,, J. Non. Cryst. Solids, vol. 357, no. 18, p.3322–3327, (2011).

DOI: 10.1016/j.jnoncrysol.2011.06.002

[3] N. Letaief et al., Effect of aging temperature on the structure, pore morphology and bioactivity of new sol-gel synthesized bioglass,, J. Non. Cryst. Solids, vol. 402, p.194–199, (2014).

DOI: 10.1016/j.jnoncrysol.2014.06.005

[4] S. O. O, N. Farhana, H. Mohamad, S. Noor, and F. Mohd, Characterization on melt-derived bioactive glass powder from SiO2-CaO-Na2O-P2O5 system,, vol. 462, p.23–31, (2017).

DOI: 10.1016/j.ceramint.2017.05.356

[5] N. F. Ibrahim, H. Mohamad, S. Noor, and F. Mohd, Development of new composition of bioactive glass powder from SiO2-CaO-Na2O-P2O5 system through melt derived route,, vol. 888, pp.267-272, (2017).

DOI: 10.1016/j.ceramint.2017.05.356

[6] N. Farhana, H. Mohamad, S. Noor, F. Mohd, and N. Ahmad, Melt-derived bioactive glass based on SiO2-CaO-Na2O-P2O5 system fabricated at lower melting temperature,, J. Alloys Compd., vol. 732, p.603–612, (2018).

DOI: 10.1016/j.jallcom.2017.10.235

[7] I. Cacciotti, M. Lombardi, A. Bianco, A. Ravaglioli, and L. Montanaro, Sol-gel derived 45S5 bioglass: Synthesis, microstructural evolution and thermal behaviour,, J. Mater. Sci. Mater. Med., vol. 23, no. 8, p.1849–1866, (2012).

DOI: 10.1007/s10856-012-4667-6

[8] M. Lombardi et al., A comparative study between melt-derived and sol-gel synthesized 45S5 bioactive glasses,, Key Eng. Mater., vol. 541, p.15–30, (2013).

DOI: 10.4028/www.scientific.net/kem.541.15

[9] C. J. Brinker and G. W. Scherer, Sol-gel science: the physics and chemistry of sol-gel processing. Academic Press, (1990).

[10] G. J. Owens et al., Progress in Materials Science Sol – gel based materials for biomedical applications,, vol. 77, p.1–79, (2016).

[11] H. Pirayesh and J. A. Nychka, Sol-gel synthesis of bioactive glass-ceramic 45S5 and its in vitro dissolution and mineralization behavior,, J. Am. Ceram. Soc., vol. 96, no. 5, p.1643–1650, (2013).

DOI: 10.1111/jace.12190

[12] Peitl Filho O, Latorre G P and Hench L, Effect of crystallization on apatite-layer formation of bioactive glass 45S5,, J. Biomed. Mater. Res., vol. 30, p.509, (1996).

DOI: 10.1002/(sici)1097-4636(199604)30:4<509::aid-jbm9>3.0.co;2-t

[13] K. Zheng et al., Aging time and temperature effects on the structure and bioactivity of gel-derived 45S5 glass-ceramics,, J. Am. Ceram. Soc., vol. 98(1), p.30–38, (2015).

DOI: 10.1111/jace.13258