Manufacturing Techniques: Polymer Implants as Drug Delivery Systems for Cancer Therapy

Abstract:

The manufacturing processes of polymeric implants for controlled drug release suggest a promising perspective of use for chemotherapeutic treatments. The objective of this study was to carry out a bibliographical survey of the last 10 years with experimental works to draw up a profile of methodologies and results achieved in this area. The literature search revealed 739 references, of which 19 were selected. The manufacturing by extrusion and injection are the most used. Regarding geographical distribution, Brazil occupies the 2nd place in the general list. The analysis of the literature on controlled release techniques of chemotherapeutic drugs demonstrates the scarce production in this area. It would be of great interest to have more studies on this topic, since it would be an alternative in the chemotherapeutic treatment.

• Periodical: Materials Science Forum (Volume 1012)
• Pages: 494-499
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.1012.494
• Online since: October 2020
• Authors: Cristiane Mayumi Wada*, Gean Vitor Salmoria
• Keywords: Additive Manufacturing, Cancer Therapy, Injection Molding, Melt Extrusion, Polymer Implants

References

[1] Moses MA, Brem H, Langer R. 2003. Advancing the field of drug delivery: Taking aim at cancer. Cancer Cell 4(5):337–341.

DOI: 10.1016/s1535-6108(03)00276-9

[2] P. Cao et al.: Journal of Pharmaceutical Sciences Vol. 103 (2014), p.945.

[3] S.S. Bansal, M.N. Vadhanam, R.C. Gupta: Pharm Res. Vol. 28 (2011), p.1121.

[4] W. Chen: Pharm. Dev. Technol. Vol. 19 (2) (2014), p.223.

[5] A.F.A.H Hanafy, A.M. El Egaky, S.A.M. Mortada, A. M. Molokhia: Drug. Discov. Ther. Vol. 3 (6) (2009), p.287.

[6] J.G. Hiremath, V.K. Devi, K. Devi A.J. Domb: Journal of Applied Polymer Science V. 107 (5) (2008), p.2745.

[7] J.G. Hiremath, V.K. Devi: Asian Journal of Pharmaceutics (2011) p.9.

[8] J.G. Hiremath, V Kusum: Asian Journal of Pharmaceutics (2013), p.125.

[9] N. Leelakanok: Antitumor Efficacy and Toxicity of 5-FU-loaded PLGA Pellets. 2018.

[10] D. Li, et al.: Drug. Deliv. Vol. 20 (2013), p.134.

[11] L. Li et al.: International Journal of Pharmaceutics Vol. 550 (2018), p.380.

[12] B.C. Masi et al.: Biomaterials Vol. 30 (2012), p.5768.

[13] C. McConville et al.: International Journal of Pharmaceutics Vol. 494 (2015), p.73.

[14] A.F. Pereira et al.: Drug Delivery Vol. 20 (3-4) (2013), p.168.

[15] G.V. Salmoria et al.: Rheumatol Orthop. Med. Vol. 2 (3) (2017), p.1.

[16] G.V. Salmoria et al.: Polymer Testing Vol. 71 (2018), p.312.

[17] G.V. Salmoria et al.: Polymer Bulletin (2018). https://doi.org/10.1007/s00289-018-2451-6.

[18] A.W. Scott: Biomaterials Vol. 32 (2011), p.2532.

[19] M. Urvashi et al.: Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain. PNAS Vol. 113 (9) (2016).

DOI: 10.1073/pnas.1600771113

[20] N. Yang et al.: International Journal of Pharmaceutics Vol. 552 (2018), p.91.