Synthesis of Calcium Phosphate Composite Bioactive Oleic Acid-Based Gels and its Application for Dentine Tubule Occlusion

Abstract:

Dentine hypersensitivity (DH) is a common issue among humans caused by the erosion of tooth enamel as a result of chewing and brushing incorrectly. The most effective treatment method is occluding the exposed dentine tubules. Because calcium phosphate is an important mineral and the most common mineral for dentine and orthopaedic application, this study focuses on the synthesis of bioactive gels containing calcium phosphate nanoparticles. The synthesis is performed using water-in-oil emulsion and characterized by the use of TGA, Rheological, TEM, and SEM techniques. This method used oleic fatty acids as an external phase and Tween 20 as surfactant to form water-in-oil nanodroplets. Gelatine was used to form the substance into a gel and increase its stability. The resulting nanoparticles had the same spherical shape and a similar size. Therefore, the varying amounts of gelatin do not affect the particle size. However, viscoelastic properties of gels were found to be changed. The ability of the gel for dentine tubule occlusion was investigated using SEM techniques. After 1 day, it was found that the gels can occlude dentine tubules.

• Periodical: Materials Science Forum (Volume 1013)
• Pages: 91-95
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.1013.91
• Online since: October 2020
• Authors: Preeyaporn Harnkla*, Orapin Chienthavorn, Khrongkhwan Akkarachaneeyakorn
• Keywords: Calcium Phosphate, Dentine Tubule Occlusion, Gels

References

[1] Brännström, M., L.Å. Lindén, and A. Åström, The Hydrodynamics of the Dental Tubule and of Pulp Fluid. Caries Research, 1967. 1(4): pp.310-317.

DOI: 10.1159/000259530

[2] Borges, A., et al., Dentin Hypersensitivity—Etiology, Treatment Possibilities and Other Related Factors: A Literature Review. World Journal of Dentistry, 2012. 3(1): pp.60-67.

DOI: 10.5005/jp-journals-10015-1129

[3] Nopteeranupharp, C., K. Akkarachaneeyakorn, and A. Songsasaen, Synthesis of Calcium Phosphate Composite Organogels by Using Emulsion Method for Dentine Occlusion Materials. IOP Conference Series: Materials Science and Engineering, 2018. 317: p.012027.

DOI: 10.1088/1757-899x/317/1/012027

[4] Deydier, E., et al., Physical and chemical characterisation of crude meat and bone meal combustion residue: Waste or raw material?,. Journal of hazardous materials, 2005. 121: pp.141-8.

DOI: 10.1016/j.jhazmat.2005.02.003

[5] El-Basheer, T., et al., Preparation and Thermal Properties of Gelatin/TGS Composite Films. Middle East J. Appl. Sci, 2015. 5: pp.157-170.

[6] Panda, B. and P.S. Goyal, Oleic acid coated magnetic nano-particles: Synthesis and characterizations. AIP Conference Proceedings, 2015. 1665(1): p.050020.

DOI: 10.1063/1.4917661

[7] Llauradó, M.C., Thermal Stability of Oleic Acid and Ethyl Linoleate. n.d.: https://www.tdx.cat/bitstream/handle/10803/8595/15.pdf?sequence=18&isAllowed=y. pp.38-45.

[8] Kishore, R.S.K., et al., Degradation of Polysorbates 20 and 80: Studies on Thermal Autoxidation and Hydrolysis. Journal of Pharmaceutical Sciences, 2011. 100(2): pp.721-731.

DOI: 10.1002/jps.22290

[9] Wu, Z., et al., Surface properties of submicrometer silica spheres modified with aminopropyltriethoxysilane and phenyltriethoxysilane. Journal of Colloid and Interface Science, 2006. 304(1): pp.119-124.

DOI: 10.1016/j.jcis.2006.08.055

[10] Olivier Lafforgue, I.S., Sébastien Poncet, Julien Favier, Rheological properties of synthetic mucus for airway clearance. Biomedical Materials Research Part A. Vol. 106. 2018. 386 - 396.

DOI: 10.1002/jbm.a.36251