Biomimetic Nanocatalysts Enhance Oxidative Damage against Cancer Cells

Zi Jin Luo; Jun Wei; Jiong Li; Ming Wu; Ya Nan Xue

doi:10.4028/p-8t7851

Paper Titles

Atmospheric Drying Process and Properties of SiO₂ Aerogels
p.3

Synthesis of Padina tetrastromatica Seaweed Mediated Silver Nanoparticles and its Toxicological Evaluation against Brine Shrimp Artemia
p.9

Biomimetic Nanocatalysts Enhance Oxidative Damage against Cancer Cells
p.15

Self-Templating Synthesized Silica Nanocapsules and Fabrication of Nanocomposite for Enhancing the Anti-Felting of Wool Fabrics
p.21

Research Progress on Adsorption of Water Pollutants by Nano Materials
p.33

Adsorptive Capacity Study of Mesoporous Carbon-Doped TiO₂and its Application in Cu(II) Removal from Water
p.39

Fabrication and Performance Test of Flexible Supercapacitors Based on Three-Dimensional Graphene Hydrogel
p.45

TiO₂/ Graphene Nanotube Arrays with Enhanced Photoelectric Properties
p.51

HomeMaterials Science ForumMaterials Science Forum Vol. 1058Biomimetic Nanocatalysts Enhance Oxidative Damage...

Biomimetic Nanocatalysts Enhance Oxidative Damage against Cancer Cells

Abstract:

Red blood cells (RBCs) naturally delivery oxygen and kill pathogens through reactive oxygen species (ROS) generated from Fe-protoporphyrin component in hemoglobin, which might be also promising for cancer treatment in terms of relieving tumor hypoxia and inducing oxidative damage against cancer cells. However, the therapy efficacy is far from satisfactory due to the limited oxygen transport and ROS generation rate in tumor tissue. Herein, artificial RBCs (designated as FTP@RBCM) with radical storm production ability is developed for oncotherapy through multi-dimensional reactivity pathways of Fe-protoporphyrin based hybrid metal-organic framework (FTP, as the core), including photodynamic/chemodynamic (PDT/CDT)-like, catalase-like and glutathione (GSH) peroxidase-like activity. Meanwhile, owing to the advantages of reticuloendothelial system (RES) evasion and long circulation abilities of RBCs governed by their cell membranes (RBCMs), FTP with surface further coated with RBCMs (FTP@RBCM) could enormously accumulate at tumor site to achieve remarkably enhanced therapy efficiency.

You might also be interested in these eBooks

View Preview

Info:

Periodical:

Materials Science Forum (Volume 1058)

Pages:

15-19

DOI:

https://doi.org/10.4028/p-8t7851

Citation:

Cite this paper

Online since:

April 2022

Authors:

Zi Jin Luo, Jun Wei, Jiong Li, Ming Wu, Ya Nan Xue*

Keywords:

Metal-Organic Framework, Nanocatalyst, Radical Storm, Red Blood Cell Mimic

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] a) H. Minasyan, Immunol. Res. 2018, 66, 271; b) A. Ukidve, Z. Zhao, A. Fehnel, V. Krishnan, D. C. Pan, Y. Gao, A. Mandal, V. Muzykantov, S. Mitragotri, PNAS 2020, 117, 17727.

DOI: 10.1073/pnas.2002880117

Google Scholar

[2] a) P. Wang, X. Wang, Q. Luo, Y. Li, X. Lin, L. Fan, Y. Zhang, J. Liu, X. Liu, Theranostics 2019, 9, 369; b) X. Sun, C. Wang, M. Gao, A. Hu, Z. Liu, Adv. Funct. Mater. 2015, 25, 2386.

Google Scholar

[3] X. Liu, M. M. Jansman, L. Hosta-Rigau, Biomater. Sci. 2020, 8, 5859.

Google Scholar

[4] K. Ni, T. Aung, S. Li, N. Fatuzzo, X. Liang, W. Lin, Chem 2019, 5, 1892.

Google Scholar

[5] Y. Liu, W. Zhen, Y. Wang, S. Song, H. Zhang, J. Am. Chem. Soc. 2020, 142, 21751.

Google Scholar

[6] a) S.F. Ngiow, B. von Scheidt, H. Akiba, H. Yagita, M. W. Teng, M. J. Smyth, Cancer Res. 2011, 71, 3540; b) Y. Wolf, A. C. Anderson, V. K. Kuchroo, Nat. Rev. Immunol. 2020, 20, 173.

Google Scholar

[7] a) J.F. Liu, L. Wu, L.L. Yang, W. W. Deng, L. Mao, H. Wu, W. F. Zhang, Z. J. Sun, J. Exp. Clin. Cancer Res. 2018, 37, 44; b) K. O. Dixon, M. Tabaka, M. A. Schramm, S. Xiao, R. Tang, D. Dionne, A. C. Anderson, O. Rozenblatt-Rosen, A. Regev, V. K. Kuchroo, Nature 2021, 595, 101; c) C. Zhu, A. C. Anderson, A. Schubart, H. Xiong, J. Imitola, S. J. Khoury, X. X. Zheng, T. B. Strom, V. K. Kuchroo, Nat. Immunol. 2005, 6, 1245.

DOI: 10.1038/s41586-021-03626-9

Google Scholar

[8] F. Liu, Y. Liu, Z. Chen, J. Hematol. Oncol. 2018, 11, 126.

Google Scholar