Stable Fabrication of Chitosan/Polycaprolactone (CS/PCL) Core-Shell Nanofibers by Electrospinning

Abstract:

Chitosan (CS), with its non-toxic and antibacterial properties, and Poly(ε-caprolactone) (PCL), known for its biodegradability and biocompatibility, are crucial materials in medical applications. This study proposed a solution utilizing electrospinning to manufacture fibers with nanometer-sized core-shell structures from these materials, with CS serving as the fiber core and PCL forming the shell. The influence of manufacturing technology parameters on fiber size and morphology was thoroughly researched and investigated. The solvent system used, Chloroform/Dimethylformamide (DMF), ensured complete solubility, viscosity control, conductivity, and proper solvent evaporation. Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM) results clearly demonstrated the morphology and internal structure of the nanofibers. The water contact angle (WCA) measurements of the fiber membrane showed almost no significant change over time, indicating strong hydrophobicity of the nanofibers. Additionally, the FTIR spectrum revealed distinct core-shell layers without any blending between them, while DSC analysis showed the thermal properties of fiber membranes. In summary, the electrospinning of nanofibers proved to be stable, producing thin fibers with an average diameter of approximately 400 nm. These findings are expected to significantly enhance the applicability of CS/PCL nanofibers across various fields, including healthcare and smart agriculture.

• Periodical: Materials Science Forum (Volume 1139)
• Pages: 107-114
• DOI: https://doi.org/10.4028/p-PF2lEp
• Online since: December 2024
• Authors: Ha Nguyen Phuong, Duyen Nguyen Thu, Nguyen Thanh Liem, Vu Anh Doan*
• Keywords: Chitosan, Core-Shell Nanofibers, Electrospinning, Poly(ɛ-Caprolactone)

References

[1] H. M. Ibrahim and A. Klingner, A review on electrospun polymeric nanofibers: Production parameters and potential applications, Polymer Testing, 90 (2020) 106647.

DOI: 10.1016/j.polymertesting.2020.106647

[2] W. Ji, F. Yang, J. J. van den Beucken, Z. Bian, M. Fan, Z. Chen, and J. A. Jansen, Fibrous scaffolds loaded with protein prepared by blend or coaxial electrospinning, Acta Biomater, 6 (2010) 4199-4207.

DOI: 10.1016/j.actbio.2010.05.025

[3] N. Bhardwaj and S. C. Kundu, Electrospinning: A fascinating fiber fabrication technique, Biotechnology Advances, 28 (2010) 325-347.

DOI: 10.1016/j.biotechadv.2010.01.004

[4] Z. Sun, E. Zussman, A. L. Yarin, J. H. Wendorff, and A. Greiner, Compound Core–Shell Polymer Nanofibers by Co‐Electrospinning, Advanced Materials, 15 (2003) 1929-1932.

DOI: 10.1002/adma.200305136

[5] K. Azuma et al., Chitin, chitosan, and its derivatives for wound healing: old and new materials, J Funct Biomater, 6 (2015) 104-142.

DOI: 10.3390/jfb9020038

[6] H. Homayoni, S. A. Hosseini Ravandi, and M. Valizadeh, Electrospinning of chitosan nanofibers: Processing optimization, Carbohydrate Polymers, 77 (2009) 656-661.

DOI: 10.1016/j.carbpol.2009.02.008

[7] A. Azari, A. Golchin, M. Mahmoodinia Maymand, F. Mansouri, and A. Ardeshirylajimi, Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application, Advanced Pharmaceutical Bulletin, 12 (2021) 658-672.

DOI: 10.34172/apb.2022.070

[8] S. Koombhongse, W. Liu, and D. Reneker, Flat ribbons and other shapes by electrospinning, Journal of Polymer Science Part B: Polymer Physics, 39 (2001) 2598-2606.

DOI: 10.1002/polb.10015

[9] S. V. Fridrikh, J. H. Yu, M. P. Brenner, and G. C. Rutledge, Controlling the fiber diameter during electrospinning, Phys Rev Lett, 90 (2003) 144502.

DOI: 10.1103/physrevlett.90.144502

[10] A. Moghe and B. Gupta, Co‐axial Electrospinning for Nanofiber Structures: Preparation and Applications, Polymer Reviews - POLYM REV, 48 (2008) 353-377.

DOI: 10.1080/15583720802022257

[11] M. Ghazalian, S. Afshar, A. Rostami, S. Rashedi, and S. H. Bahrami, Fabrication and characterization of chitosan-polycaprolactone core-shell nanofibers containing tetracycline hydrochloride, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 636 (2022) 128163.

DOI: 10.1016/j.colsurfa.2021.128163

[12] M. Pakravan, M. C. Heuzey, and A. Ajji, Core-Shell Structured PEO-Chitosan Nanofibers by Coaxial Electrospinning, Biomacromolecules, 13 (2012) 412-421.

DOI: 10.1021/bm201444v

[13] Y. Lu, H. Jiang, K. Tu, and L. Wang, Mild immobilization of diverse macromolecular bioactive agents onto multifunctional fibrous membranes prepared by coaxial electrospinning, Acta Biomater, 5 (2009) 1562-1574.

DOI: 10.1016/j.actbio.2009.01.044