Formation and In Vitro and In Vivo Evaluation of Surface Modified Implants by HAp, Carbonated-HAp and Titanium Oxide

Masazumi Okido; Ryoichi Ichino; Kotaro Kuroda

doi:10.4028/www.scientific.net/MSF.539-543.687

Paper Titles

Different Processing Methods to Obtain Porous Structure in Shape Memory Polymers
p.663

Carbon Nanotubes Grown by Catalytic CVD on Silicon Based Substrates for Electronics Applications
p.669

Variation in Bone Quality during Regenerative Process
p.675

Fretting Fatigue Studies of Surface Modified Biomedical Titanium Alloys
p.681

Formation and In Vitro and In Vivo Evaluation of Surface Modified Implants by HAp, Carbonated-HAp and Titanium Oxide
p.687

U.S. FDA Perspective on the Regulation of Cyanoacrylate Polymer Tissue Adhesives in Clinical Applications
p.692

Trivalent and Hexavalent Chromium Issues in Medical Implants
p.698

Cell Interactions with PDMS Surfaces Modified with Cell Adhesion Peptides Using a Generic Method
p.704

In Vivo and In Vitro Evaluation of Coated HAp Films with Different Surface Morphology
p.710

HomeMaterials Science ForumMaterials Science Forum Vols. 539-543Formation and In Vitro and In Vivo Evaluation of...

Formation and In Vitro and In Vivo Evaluation of Surface Modified Implants by HAp, Carbonated-HAp and Titanium Oxide

Abstract:

Hydroxyapatite (Ca10(PO4)6(OH)2, HAp), carbonated HAp and titanium oxide are of interest for bone-interfacing implant applications, because of their demonstrated osteoconductive properties. They were coated on the titanium implants and investigated the in vitro and in vivo performance. HAp coatings were performed by the thermal substrate method in aqueous solutions. Titanium oxide film was also formed on the titanium implants by gaseous oxidation, or by anodizing in the acidic solution. All the specimens covered with HAp, carbonated HAp or TiO2 (rutile or anatase). were characterized by XRD, EDX, FT-IR and SEM. In the in vitro testing, the mouse osteoblast-like cells (MC3T3-E1) were cultured on the coated and non-coated specimens for up to 30 days. Moreover, the osseointegration was evaluated from the rod specimens implanted in rats femoral for up to 8 weeks. In in vivo evaluations two weeks postimplantation, new bone formed on the coated and non-coated titanium rods in the cancellous bone and cortical bone, respectively. Bone-implant contact ratio, in order to evaluate of new bone formation, was significantly depended on the compound formed on the titanium implant.