Silicon Nitride Surface Modification and Cell Adhesion

Abstract:

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Silicon microelectrode arrays (Si MEAs) have great potential in recording of neural activity; the biocompatibility of silicon nitride has gained much attention as a part of Si MEAs. In this study, we used alternating polycations, polyethyleneimine (PEI), and polyanions, gelatin, to fabricate multilayer films built up by LbL deposition on silicon nitride wafers. Then the samples surfaces were characterized by contact angle system and atomic force microscopy (AFM). The amount of proteins adsorbed on silicon nitride and modified silicon nitride were measured by a modified Coomassie brilliant blue (CBB) protein assay. Cell culture results showed that the modified silicon nitride could increase the adhesion ability of the hippocampal neurons.

Info:

Periodical:

Materials Science Forum (Volumes 610-613)

Main Theme:

Edited by:

Zhong Wei Gu, Yafang Han, Fu Sheng Pan, Xitao Wang, Duan Weng and Shaoxiong Zhou

Pages:

1022-1025

DOI:

10.4028/www.scientific.net/MSF.610-613.1022

Citation:

Y. Zhao et al., "Silicon Nitride Surface Modification and Cell Adhesion", Materials Science Forum, Vols. 610-613, pp. 1022-1025, 2009

Online since:

January 2009

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Price:

$35.00

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