Evaluation and Control of Crystallographic Alignment of Biological Apatite Crystallites in Bones
Our group focused on the preferential degree of biological apatite (BAp) c-axis, an important bone quality parameter based on the microstructural anisotropy in intact, pathological, and regenerated bones. The preferential degree of the BAp c-axis strongly depends on the bone position, in vivo stress distribution, bone growth, degree of pathology and regeneration, activity of bone cells, gene defect, etc. We attempted to challenge clarification of the BAp preferential alignment formation mechanism and control the degree of BAp orientation by using an anisotropic biomaterial design to develop suitable distribution of the BAp c-axis orientation.
Jian-Feng Nie and Allan Morton
T. Nakano et al., "Evaluation and Control of Crystallographic Alignment of Biological Apatite Crystallites in Bones", Materials Science Forum, Vols. 654-656, pp. 2212-2215, 2010