Fabrication of Artificial Bone by the Combination of Electrospinning, Extrusion and Slurry Processes

Article Preview

Abstract:

In this work, we focused on the manufacture of artificial bone for medical replacement based on the combination of individual properties of ceramic and polymer. Here, periosteum was fabricated with a HAp (Hydroxylapatite) frame, while compact bone was fabricated from multi-layer electro-spun PS (polystyrene)/PCL (polycaprolactone) using biocompatible collagen glue. Spongy bone is formed from PCL/PLGA spongy loading BCP (Biphasic Calcium Phosphate) powder coated collagen. SEM images showed successful fabrication of the artificial bone scaffold through a combination of electro-spinning, extrusion, and use of the slurry method.

You might also be interested in these eBooks

Info:

Periodical:

Materials Science Forum (Volumes 654-656)

Pages:

2233-2236

Citation:

Online since:

June 2010

Export:

Price:

Permissions CCC:

Permissions PLS:

Сopyright:

© 2010 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

[1] Information on http: /www. nytimes. com/2009/04/28/science/28angi. html?_r=2.

Google Scholar

[2] F. H. Netter: Musculoskeletal system: anatomy, physiology, and metabolic disorders (CibaGeigy Corporation Publication, New Jersey, 1987).

Google Scholar

[3] Information on http: /www. feppd. org/ICBDent/campus/biomechanics_in_dentistry/ldv_data/mech/basic_bon e. htm.

Google Scholar

[4] L. Ghasemi-Mobarakeh, M.P. Prabhakaran, M. Morshed, M. -H. Nasr-Esfahani and S. Ramakrishna. Biomaterials. Vol. 29 (2008), p.4532.

DOI: 10.1016/j.biomaterials.2008.08.007

Google Scholar

[5] G. Eda, J. Liu and S. Shivkumar, Mater. Let. Vol. 61 (2007), p.1451.

Google Scholar

[6] J. M. Curran, Z. Tang and J. A. Hunt. J. Biomed. Materials Research Part A DOI: 10. 1002/jbm. a. 31966.

Google Scholar

[7] Z. G. Tang and J. A. Hunt, Biomaterials. Vol 27 (2006), p.4409.

Google Scholar

[8] B. -T. Lee, M. -H. Youn, R. K. Paul, K. -H. Lee, H. -Y. Song. Mater. Chem. & Phys. Vol. 104 (2007), p.249.

Google Scholar

[9] J. -K. Han, H. -Y. Song., F. Saito, B. -T. Lee, Mater. Chem. & Phys. Vol. 99 (2006), p.235.

Google Scholar

[10] B. T. Lee, S. K. Sakar, A. K. Gain, S. -J. Yim, H. Y. Song. Mater. Sci. & Eng. A Vol. 432 (2006), p.317.

Google Scholar

[11] X. Zheng, C. A. Wilkie. Polym. Degrad. & Stabi. Vol. 82 (2003), p.441.

Google Scholar