Fabrication of Artificial Bone by the Combination of Electrospinning, Extrusion and Slurry Processes
In this work, we focused on the manufacture of artificial bone for medical replacement based on the combination of individual properties of ceramic and polymer. Here, periosteum was fabricated with a HAp (Hydroxylapatite) frame, while compact bone was fabricated from multi-layer electro-spun PS (polystyrene)/PCL (polycaprolactone) using biocompatible collagen glue. Spongy bone is formed from PCL/PLGA spongy loading BCP (Biphasic Calcium Phosphate) powder coated collagen. SEM images showed successful fabrication of the artificial bone scaffold through a combination of electro-spinning, extrusion, and use of the slurry method.
Jian-Feng Nie and Allan Morton
T. H. Nguyen and B. T. Lee, "Fabrication of Artificial Bone by the Combination of Electrospinning, Extrusion and Slurry Processes", Materials Science Forum, Vols. 654-656, pp. 2233-2236, 2010