Biomimetic Artificial Cortical Bone with Aligned Microstructure Formed by a Combination of Multi-Extrusion and Rolling Processes

Abstract:

The HAp-(t-ZrO2) ceramic composites with mimetic osteon microstructures were fabricated to investigate the technical feasibility of fabricating natural bone mimetics by a combination of multi-extrusion and rolling processes. The HAp and graphite powders were mixed with ethylene vinyl acetate and stearic acid using a shear mixer, and the mixture was extruded by the multi-extrusion process to create filaments. A HAp sheet was prepared by a rolling process. The HAp filaments and carbon filaments were arranged one by one on the HAp sheet, and the system was rolled to form a mimetic osteon microstructure. Burning out and sintering processes were performed for removal of the organic binder and graphite and for densification. The pore diameter and core of the mimetic osteon microstructure were approximately 50μm and 150μm, respectively. The porosity and bending strength were approximately 60% and 177MPa, respectively in the sample sintered at 1450°C.

• Periodical: Materials Science Forum (Volumes 654-656)
• Pages: 2237-2240
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.654-656.2237
• Online since: June 2010
• Authors: Dong Woo Jang, Swapan Kumar Sakar, Min Sung Kim, Yong Ki Min, Ho Yeon Song, Byong Taek Lee
• Keywords: Cortical Bone, HAp, Microstructure, Multi-Extrusion, Osteon

References

[1] Zhongzhong Chena, *, Zhijian Sua, Shenggang Maa, Xiaoling Wua, Zhiying Luob: Computer methods and programs in biomedicine (2007) I23-I30.

[2] Hulbert SF, Young FA, Mathews RS, Klawitter JJ, Talbert CD: J Biomed Mater Res 1970, 4: 433-56.

[3] Soballe K, Brockstedt-Rasmussen H, Hansen ES, Bunger C: Acta Orthop Scand 1992, 63: 128-40.

[4] Stephenson PK, Freeman MA, Revell PA, Germain J, Tuke M: J Arthroplasty 1991, 6: 51-8.

[5] Yuan H, Van Den Doel M, Li S, Van Blitterswijk CA, De Groot K, De Bruijn JD: J Mater Sci Mater Med 2002, 13: 1271-5.

DOI: 10.1023/a:1021191432366

[6] Hulbert SF, Morrison SJ, Klawitter JJ: J Biomed Mater Res 1972, 6: 347-74.

[7] Klawitter JJ, Bagwell JG, Weinstein AM, Sauer BW: J Biomed Mater Res 1976, 10: 311-23.

[8] Ripamonti U, Van den Heever B, Van Wyk J: Matrix 1993, 13: 491-502.

DOI: 10.1016/s0934-8832(11)80115-0

[9] Habibovic P, Yuan H, van der Valk CM, Meijer G, van Blitterswijk CA, de Groot K: Biomaterials 2005, 26: 3565-75.

DOI: 10.1016/j.biomaterials.2004.09.056

[10] Hinz P, Wolf E, Schwesinger G, Hartelt E, Ekkernkamp A: Orthopedics 2002, 25(5 Suppl): S597-600.

[11] Borrelli J Jr, Prickett WD, Ricci WM: Clin Orthop 2003, 411: 245-54.

[12] Tsai YH, Tsung-Jen H, Shih HN, Hsu RW: Chang Gung Med J 2004, 27: 542-7.

[13] Moed BR, Willson Carr SE, Craig JG, Watson JT: Clin Orthop Relat Res 2003, 410: 303-9.

[14] Daculsi G, Passuti N, Martin S, Deudon C, Legeros RZ, Raher S: J Biomed Mater Res 1990, 24: 379-96.

DOI: 10.1002/jbm.820240309

[15] Beardmore AA, Brooks DE, Wenke JC, Thomas DB: J Bone Joint Surg Am 2005, 87: 107-12.

[16] Wiltfang J, Merten HA, Schlegel KA, et al: J Biomed Mater Res 2002, 63: 115-21.

[17] Klein CP, Driessen AA, de Groot K, van den Hooff A: J Biomed Mater Res 1983, 17: 769-84.

[18] Eggli PS, Muller W, Schenk RK: Clin Orthop 1988, 232: 127-38.