This work present a low resistance dye-sensitized solar cell (DSSC) based on metal substrates. Different kinds of metal meshes are used to fabricate nanocrystalline TiO2 electrode and counter-electrode. The nanoporous TiO2 thin films were fabricated via an aerosol deposition method. The TiO2 colloid was produced by dissolving P25 powder in deionized (DI) water and atomized using an ultrasonic nebulizer. The flexible electrodes can be sintered under 450–550 °C and exhibit high-temperature sinterability. The tuning of TiO2 film thickness coated on metal mesh towards optimization of solar energy conversion efficiency had been investigated. Experimental results show that the excellent electric conductivities improve the fill factor and conversion efficiency for the large-size DSSCs due to the reduced internal resistance of the cell. These flexible metal substrates are a promising approach especially from the viewpoint of large-scale, cost effective industrial manufacturing of solar cells.