The green strength of a powder compact results from the mechanical interlocking of the irregularities on the particle surfaces. During compaction, particle rearrangement, plastic deformation and particularly surface deformation of powders occur. Titanium powder is susceptible to interstitial element contamination, which may lead to solid solution strengthening of the particles and/or the formation of non-metallic compounds on the surface. However, the influence of these various impurities, namely oxygen and nitrogen, on the green strength has not been investigated. This work investigates and quantitatively evaluates the factors influencing the green strength of the powder compacts. The indirect tensile test was applied for the determination of the green strength of the powder compacts, and test results were compared to that of a more conventional 3-point bending test. The substantial dependence of green strength on both the amount of impurity element in the core of the powder particles and the compaction pressure is demonstrated. The effect of the surface condition of the powder particles on green strength is also reported.