Development of Microcapsules Containing Oil-Based Contrast Medium
For efficient transcatheter arterial embolization therapy for hepatocellular carcinoma, we have developed microcapsules containing oil-based contrast medium, as obstructing materials. The microcapsules were prepared by means of the interfacial polymerization to make a wall membrane consisting of polyureaurethane with Lipiodol in the core. The average size of the particles was 80 μm, and the size distribution was fairly small. The extent of X-ray absorption of the microcapsules was controlled by the ratio of the amounts of triisocyanate monomer and Lipiodol in the oil phase on the interfacial polymerization.
Chengming Li, Chengbao Jiang, Zhiyong Zhong and Yichun Zhou
M. Uehara et al., "Development of Microcapsules Containing Oil-Based Contrast Medium", Materials Science Forum, Vol. 687, pp. 548-551, 2011