Development of Microcapsules Containing Oil-Based Contrast Medium

Abstract:

For efficient transcatheter arterial embolization therapy for hepatocellular carcinoma, we have developed microcapsules containing oil-based contrast medium, as obstructing materials. The microcapsules were prepared by means of the interfacial polymerization to make a wall membrane consisting of polyureaurethane with Lipiodol in the core. The average size of the particles was 80 μm, and the size distribution was fairly small. The extent of X-ray absorption of the microcapsules was controlled by the ratio of the amounts of triisocyanate monomer and Lipiodol in the oil phase on the interfacial polymerization.

• Periodical: Materials Science Forum (Volume 687)
• Pages: 548-551
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.687.548
• Online since: June 2011
• Authors: Masumi Uehara, Syotaro Hamakawa, Yasuyuki Maki, Toshiaki Dobashi
• Keywords: Contrast Medium, Microcapsule, Transcatheter Arterial Embolization Therapy

References

[1] Yamada R, Sato M, et al: Radiology Vol. 148 (1983), pp.397-401.

[2] Takahashi M, Takayasu K, Arai Y: Kan Tan Sui Vol. 59 (2009), pp.819-829.

[3] Yamada R, Sawada T, et al: Jpn J Cancer Chemother Vol. 32 (2005), pp.1431-1436.

[4] Yamazaki T, Saeki K, et al: Kanzo Vol. 49 (2008), pp.25-27.

[5] Myung Joo Kang, Jung Min Park, et al: Chem. Pharm. Bull Vol. 58 (2010), pp.288-292.

[6] Kudou M, Kubo S, et al: Kanzo Vol. 51 (2010), pp.261-266.

[7] Beppu T, Ogawa M, et al: The Jpn. J. Gastroenterological Surg Vol. 31 (1998), pp.1078-1083.

[8] Ichikawa, K: J. Appl. Polym. Sci Vol. 54 (1994), p.1321.

[9] Dobashi, T., Furukawa, T., Ichikawa, K. and Narita, T. Langmuir Vol. 18 (2002), pp.6031-6034.