Preparation and Evaluation of a W/O/W Double Emulsion Containing both Vitamin C and Vitamin E

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As the instability of vitamin C and vitamin E, double emulsion was chosen as a carrier system for dermal delivery of vitamins. The present work shows how to prepare and evaluate a double emulsion containing both vitamin C and vitamin E. The double emulsion was produced by two-step process. The concentration of vitamins were analyzed by UV, and the morphology of double emulsions were observed with optical microscopic. Vitamins could be protected well in one system, which was W/O/W double emulsion. The shape of double emulsion was also an evidence for the safety of vitamins. In the end, we obtained a stable double emulsion containing both vitamin C and vitamin E for cosmetics.

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783-787

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July 2011

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© 2011 Trans Tech Publications Ltd. All Rights Reserved

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[1] M. Drach, et al., Antioxidative properties of vitamins C and E in micellar systems and in microemulsions, (2011).

Google Scholar

[2] B. Rozman and M. Gasperlin, Stability of vitamins C and E in topical microemulsions for combined antioxidant therapy, Drug Delivery, vol. 14, pp.235-245, (2007).

DOI: 10.1080/10717540601067786

Google Scholar

[3] Y. Hemar, et al., Encapsulation of Resveratrol Using Water-in-Oil-in-Water Double Emulsions, Food Biophysics, vol. 5, pp.120-127, (2010).

DOI: 10.1007/s11483-010-9152-5

Google Scholar

[4] T. Nisisako, Microstructured devices for preparing controlled multiple emulsions, Chemical Engineering & Technology, vol. 31, pp.1091-1098, (2008).

DOI: 10.1002/ceat.200800119

Google Scholar

[5] C. Laugel, et al., Oil-water-oil multiple emulsions for prolonged delivery of hydrocortisone after topical application: comparison with simple emulsions, International Journal of Pharmaceutics, vol. 160, pp.109-117, Jan (1998).

DOI: 10.1016/s0378-5173(97)00302-5

Google Scholar

[6] J. S. Lee, et al., The stabilization of L-ascorbic acid in aqueous solution and water-in-oil-in-water double emulsion by controlling pH and electrolyte concentration, Journal of Cosmetic Science, vol. 55, pp.1-12, Jan-Feb (2004).

DOI: 10.1111/j.0142-5463.2004.00223_1.x

Google Scholar

[7] N. Garti, Double emulsions - Scope, limitations and new achievements, Colloids and Surfaces a-Physicochemical and Engineering Aspects, vol. 123, pp.233-246, (1997).

DOI: 10.1016/s0927-7757(96)03809-5

Google Scholar

[8] G. Capuzzi, et al., Mixtures of Stearoyl-6-O-ascorbic Acid and α-Tocopherol:   A Monolayer Study at the Gas/Water Interface, Langmuir, vol. 12, pp.3957-3963, (1996).

DOI: 10.1021/la960001y

Google Scholar

[9] P. A. Glascott Jr and J. L. Farber, Assessment of physiological interaction between vitamin E and vitamin C, in Methods in Enzymology. vol. Volume 300, P. Lester, Ed., ed: Academic Press, 1999, pp.78-88.

DOI: 10.1016/s0076-6879(99)00116-0

Google Scholar

[10] T. Guaratini, et al., Stability of cosmetic formulations containing esters of Vitamins E and A: Chemical and physical aspects, International Journal of Pharmaceutics, vol. 327, pp.12-16, Dec (2006).

DOI: 10.1016/j.ijpharm.2006.07.015

Google Scholar

[11] F. Podlogar, et al., The effect of internal structure of selected water-Tween 40 (R)-Imwitor 308 (R)-IPM microemulsions on ketoprofene release, International Journal of Pharmaceutics, vol. 302, pp.68-77, (2005).

DOI: 10.1016/j.ijpharm.2005.06.023

Google Scholar

[12] N. Garti and C. Bisperink, Double emulsions: progress and applications, Current Opinion in Colloid & Interface Science, vol. 3, pp.657-667, (1998).

DOI: 10.1016/s1359-0294(98)80096-4

Google Scholar