In Vitro and In Vivo Studies on a MgLi-X Alloy System Developed as a New Kind of Biological Metal

Abstract:

Magnesium alloys have a good application prospect in the fields of bone implants and cardiovascular stents due to their excellent properties, such as close density and elastic modulus to those of nature bone, high specific strength and rigidity, biodegradation and biocompatibility. In this paper, the feasibility of the use of the forged Mg-Li-X alloys (Mg-Li-Al-Zn-Ca-Sr) as biodegradable metals was investigated by immersion tests in the Hanks solution and skin-tissue implantation tests. The methods of SEM-EDS and XRD were used to research the corrosion morphology and corrosion products of the forged Mg-Li-X alloys after the in-vitro and in-vivo tests. At last, the in-vitro cytotoxicity was investigated by the MTT tests on L929 cells. Results showed that corrosion mechanism of the forged Mg-Li alloys was pitting and the surfaces were covered by Mg (OH)₂,CaCO₃ and Ca (H₂PO₄)₂ . During the 5 weeks implantation period, the rats survived from the operation, which indicates that the elements and the compounds formed are non-toxic to the rats. The forged Mg-Li alloy showed Grade 0~1 cytotoxicity, which manifests the forged Mg-Li alloy has good biocompatibility and eligible toxicity for implant applications.

• Periodical: Materials Science Forum (Volumes 747-748)
• Pages: 257-263
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.747-748.257
• Online since: February 2013
• Authors: Sha Luo, Qing Qing Zhang, Yan Chang Zhang, Chao Li, Xiao Qing Xu, Tie Tao Zhou
• Keywords: Biocompatibility, Biodegradability, Corrosion, Magnesium Alloy

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