Preparation of Drug Loaded Polyurethane Thin Layer on the Silicone Tube by Electrospinning Technique for Stent Application

Dong Geun Shin; Y.J. Lee; Y. Kim; W.T. Kwon; S.R. Kim; Doh Hyung Riu

doi:10.4028/www.scientific.net/MSF.804.131

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HomeMaterials Science ForumMaterials Science Forum Vol. 804Preparation of Drug Loaded Polyurethane Thin Layer...

Preparation of Drug Loaded Polyurethane Thin Layer on the Silicone Tube by Electrospinning Technique for Stent Application

Abstract:

Drug loaded polyurethane (PU) thin layer was prepared on the silicone tube by electrospinning technique. Microstructure of the PU layer was varied from nanoporous web to dense coating depending on the polymer solution concentration and the amount of drug loaded. It can be easily adjusted the coating thickness and porosity accurately and controlled the drug loading and releasing properties. However, adhesive strength between PU layer and silicone tube was very weak and easily broken away and white turbidity also another important problem. So, surface of silicone tube was atmospheric-pressure plasma (APP) treated for improving the adhesive and removing white turbidity phenomenon.

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Periodical:

Materials Science Forum (Volume 804)

Pages:

131-134

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.804.131

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Online since:

October 2014

Authors:

Dong Geun Shin*, Y.J. Lee, Y. Kim, W.T. Kwon, S.R. Kim, Doh Hyung Riu

Keywords:

APP, Coating, Drug Loading, Electrospinning, Stent

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