Nano-Cu/Low-Density Polyethylene Composites: Structure and Control Release of Cupric Ions

Abstract:

In recent years a new type of intrauterine device (nanoCu/LDPE composites) has been concerned by a lot of scholars for its short release time, high bioavailability and good biocompatibility. In this study nanoCu/low-density polyethylene composites were prepared by extruding mixtures of pure LDPE and nanoCu using melt-blending method, the release rate of cupric ions (Cu²⁺) was measured in simulated uterine fluid. The non-isothermal crystallization behavior and thermal stability of the composites before and after immersion were studied by differential scanning calorimetry (DSC) and thermogravimetric analyzer (TG). The results showed that Composites effectively shorten the time of the copper ion "burst release" , the burst release phenomenon of Cu²⁺ occurred during the first five days after immersion , and then tend to stable . By immersion the crystallinity of composites increased, and the thermal stability decreased.

• Periodical: Materials Science Forum (Volume 848)
• Pages: 72-76
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.848.72
• Online since: March 2016
• Authors: Yu Qiu, Hua Lei, Tao Xu
• Keywords: Composites, Nano-Cu, Release of Cupric Ion, Thermal Stability

References

[1] I. Mavranezouli, The cost-effectiveness of long-acting reversible contraceptive methods in the UK: analysis based on a decision-analytic model developed for a National Institute for Health and Clinical Excellence (NICE) clinical practice guideline, Hum Reprod, 23(2008).

DOI: 10.1093/humrep/den091

[2] P. D. Blumenthal, A. Voedisch, K. Gemzell-Danielsson, Strategies to prevent unintended pregnancy: increasing use of long-acting reversible contraception, Hum Reprod Update, 17(2010) 121-137.

DOI: 10.1093/humupd/dmq026

[3] T. von Werne, T. E. Patten, Preparation of structurally well defined polymer–nanoparticle hybrids with controlled/living radical polymerization , Journal of the American Chemistry Society , 121(1999) 7409–7410.

DOI: 10.1021/ja991108l

[4] M. Thiery, Intrauterine contraception: from silver ring to intrauterine contraceptive implant, European Journal of Obstetrics & Gynecology & Reproductive Biology, 90(2000) 145-152.

DOI: 10.1016/s0301-2115(00)00262-1

[5] F. Zielske , J. U. Koch , R. Badura , et al , Studies on copper release from copper-T devices (T-CU 200) and its influence on sperm migration in vitrok, Contraception , 10(1975) 651-666.

DOI: 10.1016/0010-7824(74)90104-8

[6] J. A. Zipper , H. J. Tatum, L. Pastene , et al , Metallic copper as a intrauterine contraceptive adjunct to T, device , American Journal of Obstetrics & Gynecology , 1970 , 105.

DOI: 10.1016/0002-9378(69)90302-0

[7] Y. Liu , A. Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Engineering , Huazhong University of Science and Technology , 2011.

[8] W. Zhang , X. Xia , C. Qi , C. Xie, S. Cai, A porous Cu/LDPE composite for copper-containing intrauterine contraceptive devices , Acta Biomater , 8(2012) 897-903.

DOI: 10.1016/j.actbio.2011.09.024

[9] E. Fulcher, N. R. Elisa Di Capua, Pregnancy despite IUD: adverse effect on pregnancy evolution and fetus, (2003).

DOI: 10.1016/s0010-7824(03)00074-x

[10] L. Xiao, Control of pore structure in copper/low density polyethylene porous composites, Huazhong University of Science and Technology, (2013).

[11] T. Xu, H. Lei, S. Z. Cai, X. P. Xia, C. S. Xie, The release of cupric ion in simulated uterine: New material nano-Cu/low-density polyethylene used for intrauterine devices, Contraception, 70(2004) 153-157.

DOI: 10.1016/j.contraception.2004.02.018