Effects of Hydroxyapatite/Silk Fibroin/Chitosan Ratio on Physical Properties of Scaffold for Tissue Engineering Application

Wassanai Wattanutchariya; Atitaya Oonjai; Kittiya Thunsiri

doi:10.4028/www.scientific.net/MSF.872.261

Paper Titles

The Improvement in Mechanical and Thermal Properties of Biodegradable Poly(Butylene Succinate) (PBS) Nanocomposites with Low Loadings of Graphene Oxide (XGO)
p.235

Preparation of Zeolite Nanocrystals via Hydrothermal and Solvothermal Synthesis Using of Rice Husk Ash and Metakaolin
p.242

Effects of TEOS Precursor and Reaction Time on the Synthesis of Silica Coated Single-Walled Carbon Nanotubes
p.248

Characterization of Bismuth Vanadate Nanopowder Prepared by Microwave Method
p.253

Effects of Hydroxyapatite/Silk Fibroin/Chitosan Ratio on Physical Properties of Scaffold for Tissue Engineering Application
p.261

Comparative Studies of the Light Yield Non-Proportionality and Energy Resolution of CsI(Tl), LYSO and BGO Scintillation Crystals
p.266

Compressive Strength Development of High Strength High Volume Fly Ash Concrete by Using Local Material
p.271

Study on the Performance of Orthodontic Self-Drilling Correction Screw of Ti6Al4V and Stainless 316L
p.276

Influence on Fatigue and Biomechanics of Cone Fit of Dental Implant around the Surrounding Bone Tissue
p.281

HomeMaterials Science ForumMaterials Science Forum Vol. 872Effects of Hydroxyapatite/Silk Fibroin/Chitosan...

Effects of Hydroxyapatite/Silk Fibroin/Chitosan Ratio on Physical Properties of Scaffold for Tissue Engineering Application

Abstract:

This study reports the effects of the mixing ratio of hydroxyapatite (HA), silk fibroin (SF) and chitosan (CS) on the physical properties of the scaffold used in tissue engineering. Experimental design based on mixture design was implemented to investigate the degradation rate of the scaffolds fabricated from various ratios of those biomaterials. Furthermore, pore morphology and pore size were evaluated to confirm the compatibility of the scaffold topography for cell growth and adhesion. The results from the study showed that all ratios, except pure HA solution, can be fabricated into porous scaffolds with an interconnected pore structure and appropriate pore sizes to allow all types of human cells to pass through. Furthermore, the scaffold solutions with high CS ratio resulted in a uniform pore structure and lower rates of biodegradation. Therefore, CS is recommended as the main structure because it provides the highest resistance to biodegradation. The scaffolds from various ratios may be applied for different tissue replacements in the near future.

You might also be interested in these eBooks

Material and Manufacturing Technology VII

View Preview

Info:

Periodical:

Materials Science Forum (Volume 872)

Pages:

261-265

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.872.261

Citation:

Cite this paper

Online since:

September 2016

Authors:

Wassanai Wattanutchariya*, Atitaya Oonjai, Kittiya Thunsiri

Keywords:

Biomaterials, Lyophilization, Mixture Design, Physical Properties, Scaffold, Tissue Engineering

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

Citation:

* - Corresponding Author

References

[1] CM. Murphy, FJ. O'Brien, DG. Little and A Schindeler: Eur Cell Mater Vol. 26 (2013), p.120.

Google Scholar

[2] W. Wattanutchariya and P. Yenbut: Advanced Materials Research Vols. 931-932 (2014), p.301.

Google Scholar

[3] T. Sukhachiradet and W. Wattanutchariya: Advanced Materials Research Vol. 849 (2014), p.151.

Google Scholar

[4] K. Thunsiri, S. Udomsom, and W. Wattanutchariya: Key Engineering Materials Vols. 675-676 (2016), p.459.

DOI: 10.4028/www.scientific.net/kem.675-676.459

Google Scholar

[5] W. Wattanutchariya and K. Thunsiri: Applied Mechanics and Materials Vols. 675-676 (2015), p.488.

Google Scholar

[6] S.V. Madihally, and H.W. Matthew: Biomaterials, Vol. 20 Issue 12 (1999. ), p.1133.

Google Scholar

[7] N. Bhardwaj and S. C. Kundu: Carbohydrate Polymers, Vol. 85 (2011), p.325.

Google Scholar

[8] R. Rujiravanit, S. Kruaykitanon, A.M. Jamieson, and S. Tokura: Macromol. Biosci, Vol. 3 (2003), p.604.

Google Scholar

[9] M.H. Ross, E.J. Reith, and L.J. Romrell: Histology: A Text and Atlas, Second Edition (Williams & Wilkins, Baltimore MD 1989).

Google Scholar

[10] M.A. Moraes, G.M. Nogueira, R.F. Weska, and M.M. Beppu: Polymers, Vol. 2 (2010), p.719.

Google Scholar

[11] S. Bose, M. Roy, and A. Bandyopadhyay: Trends in biotechnology. Vol. 30 Issue 10 (2012), p.546.

Google Scholar