Superelasticity of Ti-Nb-Zr Alloys and their Medical Application

Abstract:

In this paper investigation results of behavior of promising superelastic alloys of Ti-Nb-Zr system in blood-vessel are presented. The possibility of their use in manufacturing of medical stents is examined. Based on analytical review of present scientific papers, four different alloys of Ti-Nb-Zr system are taken in consideration. A finite element modelling of stent behavior during delivery and opening stages is considered. These processes are done for two typical stent geometries and four alloys possessing different mechanical properties. Finite modelling results are analyzed to show the distribution of internal stresses, mechanical aspects of stent installation and effectiveness of various configurations to widen the narrowed vessel. Modeling has allowed to formulate recommendations for optimal mechanical characteristics of the superelastic alloy used for the manufacture of medical stents.

• Periodical: Materials Science Forum (Volume 879)
• Pages: 2561-2566
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.879.2561
• Online since: November 2016
• Authors: Margarita Isaenkova*, Yuriy Perlovich, Elizaveta Efimova, Dmitry Zhuk, Olga Krymskaya
• Keywords: Finite Element Method, Martensitic Transformation, Stent, Superelastic Ti-Nb-Zr Alloys, Superelasticity

References

[1] F. Shawl, W. Kadro, M. J. Domanski, F. L. Lapetina, A. A. Iqbal, K. G. Dougherty, S. T. Shahab, Safety and efficacy of elective carotid artery stenting in high-risk patients. Journal of the American College of Cardiology 35(7) (2000) 1721-1728.

DOI: 10.1016/s0735-1097(00)00618-5

[2] C. C. Shih, S. J. Lin, Y. L. Chen, Y. Y. Su, S. T. Lai, G. J. Wu, K. H. Chung, The cytotoxicity of corrosion products of nitinol stent wire on cultured smooth muscle cells. Journal of biomedical materials research (2000) 52(2) 395-403.

DOI: 10.1002/1097-4636(200011)52:2<395::aid-jbm21>3.0.co;2-b

[3] T. W. Duerig, D. E. Tolomeo, M. Wholey, An overview of superelastic stent design. Minimally Invasive Therapy & Allied Technologies 9(3-4) (2000) 235-246.

DOI: 10.3109/13645700009169654

[4] H.Y. Kim, Y. Ikehara, J.I. Kim, H. Hosoda, S. Miyazaki, Martensitic transformation, shape memory effect and superelasticity of Ti–Nb binary alloys. Acta Materialia 54 (2006) 2419–2429.

DOI: 10.1016/j.actamat.2006.01.019

[5] C.G. Caro, T.J. Pedley, R.C. Schroter, W.A. Seed, The mechanics of the circulation. Moscow Mir 11 (1981) 624.

[6] F. Sun, Y.L. Hao, S. Nowak, T. Gloriant, P. Laheurte, F. Prima, A thermo-mechanical treatment to improve the superelasti performances of biomedical Ti–26Nb and Ti–20Nb–6Zr (at. %) alloys. Journal of the mechanical behavior of biomedical materials (2011).

DOI: 10.1016/j.jmbbm.2011.06.003

[7] J. Zhang, Fan Sun, Y. Hao, N. Gozdecki, E. Lebrun, P. Vermaut, R. Portier, T. Gloriant, P. Laheurte, F. Prima, Influence of equiatomic Zr/Nb substitution on superelastic behavior of Ti–Nb–Zr alloy. Materials Science & Engineering A 563 (2013).

DOI: 10.1016/j.msea.2012.11.045

[8] H. Tobe, H.Y. Kim, S. Miyazaki, Effect of Nb content on deformation textures and mechanical properties of Ti-18Zr-Nb biomedical alloys. Materials Transactions (2009) Vol. 50 (12) 2721-2725.

DOI: 10.2320/matertrans.ma200908

[9] M. Tahara, H.Y. Kim, T. Inamura, H. Hosoda, S. Miyazaki, Effect of nitrogen addition on superelasticity of Ti-Nb-Zr alloys. Materials Transactions (2009) 50(12) 2726-2730.

DOI: 10.2320/matertrans.ma200907

[10] J. Il. Kim, H. Yo. Kim, T. Inamure, H. Hosoda, S. Miyazaki, Effect of annealing temperature on microstructure and shape memory characteristics of Ti-22Nb-6Zr (at. %) biomedical alloy. Materials Transactions (2006) 47 (3) 505-512.

DOI: 10.2320/matertrans.47.505

[11] H.Y. Kim, J. Fu, H. Tobe, S. Miyazaki, Shape Memory and Superelasticity (2015) 1 107.