Pluronic-PEI Micelles Reverse Multidrug Resistance by Depleting ATP and Inhibiting P-Glycoprotein for Colon Cancer Therapy

Abstract:

We have designed a polymer micelles based on Pluronic P₁₂₃ and Polyethyleneimine 600 (termed as P₁₂₃P₆₀₀). Upon critical micelle concentration the P₁₂₃P₆₀₀ unimer formed micelles in water. These micelles not only could simultaneously delivery hydrophobic anticancer drug paclitaxel (PTX) to cancer cells but also could deplete ATP and inhibit P-gp expression in MDR cells. In vitro researches demonstrated that these micelles showed the excellent biocompatibility, high drug loading efficiency, stably controlled releasing behavior, enhanced cellular up-take and improved serum stability. In vivo studies demonstrated that the PTX loaded micelles induced tumor cell apoptosis and inhibited the growth of tumor to overcome drug resistance through a synergistic effect. All these findings suggested that P₁₂₃P₆₀₀ for delivery of anticarcinogen provided a promising strategy for reversal of MDR in cancer treatment.

• Periodical: Materials Science Forum (Volume 886)
• Pages: 111-116
• DOI: https://doi.org/10.4028/www.scientific.net/MSF.886.111
• Online since: March 2017
• Authors: He Bin Wang, Yang Li, Kai Hang Liu, Jun Zhou, Gu Ping Tang*
• Keywords: ATP, Drug Delivery, Multidrug Resistance, P-Glycoprotein, Pluronic

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