Synthesis of Curcumin Analogs under Ultrasound Irradiation for Inhibiting α-Amylase

Lana D.T. Tantriasa; Chairil Anwar; Endang Astuti

doi:10.4028/www.scientific.net/MSF.948.115

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HomeMaterials Science ForumMaterials Science Forum Vol. 948Synthesis of Curcumin Analogs under Ultrasound...

Synthesis of Curcumin Analogs under Ultrasound Irradiation for Inhibiting α-Amylase

Abstract:

Curcumin has biological properties because of its special characteristic of structure. Mono-ketone analogs curcumin show a better pharmacokinetics than curcumin itself. Curcumin analogs 1 and 2 were synthesized from 3,5-dimethoxybenzaldhyde and acetone (analog 1) and cyclohexanone (analog 2) under ultrasound irradiation at room temperature for 15-30 minutes and the yield of each analogs is 82.40% and 77.52%. Analog curcumin 1 and 2 were tested the inhibitory activity towards α-amylase enzyme with acarbose as a positive control. The inhibitory activity of α-amylase is determined by measure the descent of iodine-starch complex using Tecan Spark-Multimode Microplate Reader. Acarbose gives 42.9% inhibition activity at 12.5 mg/L concentration whereas analog 1 shows an inhibition activity 48.5% at 50 mg/L concentration and analog 2 gives 45.8% inhibition activity at 25 mg/L concentration. Hence analog 1 and analog 2 has a potential as an inhibitory agent of α-amylase which performs a better activity than acarbose.

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Materials Science Forum (Volume 948)

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115-119

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https://doi.org/10.4028/www.scientific.net/MSF.948.115

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March 2019

Authors:

Lana D.T. Tantriasa, Chairil Anwar*, Endang Astuti

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Curcumin, Synthesis, Ultrasound, α-Amylase

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